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Book Cover
E-book
Author Meyer, Jonathan M., 1962- author

Title The clinical use of antipsychotic plasma levels / Jonathan M Meyer, Stephen M Stahl ; with illustrations by Nancy Munter
Published Cambridge ; New York, NY : Cambridge University Press, 2021

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Description 1 online resource
Series Stahl's handbooks
Stahl's handbooks
Contents Sampling times for oral and long acting injectable agents -- The therapeutic threshold and the point of futility -- Level interpretation including laboratory reporting issues, responding to high plasma issues, responding to high plasma levels, special situations (hepatic dysfunction, renal dysfunction and hemodialysis, bariatric surgery) -- Tracking oral antipsychotic adherence -- What is an adequate antipsychotic trial-using plasma levels to optimize psychiatric response and tolerability -- Important concepts about first generation antipsychotics -- Haloperidol and haloperidol decanoate -- Fluphenazine and fluphenazine decanoate -- Perphenazine and perphenazine decanoate -- Zuclopenthixol and zuclopenthixol decanoate; flupenthixol and flupenthixol decanoate -- Chlorpromazine, loxapine, thiothixene, trifluoperazine -- Important concepts about second generation antipsychotics -- Clozapine -- Risperidone oral and long acting injectable, paliperidone oral and long acting injectable -- Olanzapine and olanzapine pamoate -- Aripiprazole, aripiprazole monohydrate and aripiprazole lauroxil -- Amisulpride, asenapine, lurasidone, brexpiprazole, cariprazine
Summary "The use of antipsychotics to treat schizophrenia is fraught with many layers of complexity, as prescribers try to tailor the pharmacodynamic properties of an agent to a specific patient based primarily on subjective response. Variations in drug metabolism related to genetic polymorphisms, or to medication or environmental exposures (e.g. smoking), and variable adherence with oral medications lead to scenarios that confound even seasoned clinicians. Excluding the realization that up to one-third of schizophrenia patients may not respond adequately to non-clozapine antipsychotics, 60 years of antipsychotic research has demonstrated that dose is a poor correlate of response likelihood, whereas plasma drug levels represent the best clinically available tool that quantifies the relationship between drug exposure and central nervous system (CNS) activity.[1] The classic equation by psychopharmacologist Sheldon Preskorn illustrates the variables involved in clinical drug response (Figure 1.1)"-- Provided by publisher
Bibliography Includes bibliographical references and index
Notes Description based on print version record and CIP data provided by publisher; resource not viewed
Subject Antipsychotic drugs.
Psychoses -- Chemotherapy.
Drugs -- Dose-response relationship.
Antipsychotic Agents -- blood
Dose-Response Relationship, Drug
Antipsychotic Agents -- therapeutic use
Psychotic Disorders -- drug therapy
Schizophrenia -- drug therapy
Antipsychotic Agents
MEDICAL / Mental Health.
Drugs -- Dose-response relationship
Antipsychotic drugs
Psychoses -- Chemotherapy
Form Electronic book
Author Stahl, Stephen M., 1951- author
LC no. 2021012649
ISBN 9781009002103
1009002104