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Author Bodensee Symposium on Microcirculation (17th : 2002 : Lindau, Bavaria, Germany)

Title Microcirculatory effects of hemoglobin solutions / 17th Bodensee Symposium on Microcirculation, Lindau, June 21-23, 2002 ; volume editors, K. Messmer, K.E. Burhop, J. Hutter
Published Basel ; New York : Karger, ©2004


Description 1 online resource (x, 106 pages) : illustrations (some color)
Series Progress in applied microcirculation, 0254-5195 ; v. 25
Progress in applied microcirculation ; v. 25. 0254-5195
Summary Solutions of stroma-free hemoglobin have been investigated for their potential as blood replacement fluids for more than 70 years. Despite many attempts to overcome their unwanted side effects through chemical modification of the hemoglobin molecule, none of the potential solutions has been approved for clinical use in Europe or the United States. In recent years, the vasoconstrictive activity of hemoglobin in the plasma was identified as the pivotal problem of hemoglobin-based blood substitutes, compromising nutritional perfusion and thus impeding oxygen unloading at the site of the microcirculation. One of the prevailing assumptions is that the precapillary vasoconstriction and the ensuing tissue underperfusion is caused by the high affinity of free hemoglobin for nitric oxide. To resolve this problem, a number of recombinant techniques involving site-directed mutagenesis as well as several chemical approaches involving polymerization and pegylation have been developed. This volume summarizes the latest research on the effects of some of these new hemoglobin solutions on the microvasculature and tissue oxygenation. It is recommended reading for all those interested in finding alternatives for donor blood in transfusion medicine, including emergency specialists, anesthesiologists, surgeons, trauma surgeons and other clinicians who are frequently confronted with blood loss and the need for blood replacement
Bibliography Includes bibliographical references and indexes
Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. MiAaHDL
Print version record
digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL
Subject Blood substitutes -- Congresses
Hemoglobin -- Therapeutic use -- Congresses
Microcirculation -- Congresses
Blood Substitutes -- adverse effects
Blood Substitutes -- pharmacokinetics
Blood Substitutes -- therapeutic use
Hemoglobins -- adverse effects
Hemoglobins -- pharmacokinetics
Hemoglobins -- therapeutic use
Blood substitutes
Substituts sanguins.
Sang -- Substituts -- Congrès.
Hémoglobine -- Emploi en thérapeutique -- Congrès.
Microcirculation -- Congrès.
Genre/Form proceedings (reports)
Conference papers and proceedings
Conference papers and proceedings.
Actes de congrès.
Form Electronic book
Author Messmer, K
Burhop, K. E
Hutter, J
ISBN 9783318010688