Title Diversity, versatility, and leukaemia / Geoffrey Brown and Isidro Sánchez-García

Published New York : Nova Biomedical, [2016]

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Description 1 online resource Series cancer etiology, diagnosis and treatments Cancer etiology, diagnosis, and treatments. Contents DIVERSITY, VERSATILITY AND LEUKAEMIA ; DIVERSITY, VERSATILITY AND LEUKAEMIA ; Library of Congress Cataloging-in-Publication Data; Contents ; Preface; Short Abstract; Acknowledgments; Chapter 1 The Diversity of Blood Cells ; Introduction; Red and Colourless Corpuscles; The Various Major Blood and Immune Cell Types; Innate Immune Cells -- The Immediate Line of Defence; The Adaptive Immune System; Delineating Cell Lineages; Conclusion; References; Chapter 2 The Conventional Viewpoint to Hematopoiesis Introduction ; The Nature of Haematopoietic Stem Cells Compartmentalisation of Developing Blood CellsTwo Families of Cells; A Single and Preferred Route to a Particular Cell Fate; Conclusion; References; Chapter 3 Revision to the Model of Haematopoiesis ; Introduction; Is There Just a Single Family of Blood Cells?; The True Nature of Haematopoietic Stem Cells; The Versatility of Developmental Pathways; Revising the Classic Model for Haematopoiesis; The Instructive Action of Haematopoietic Growth Factors; Conclusion; References; Chapter 4 Classifying the Various Leukaemias/Haematopoietic Cancers ; Introduction Classification of Leukaemias/Haematopoietic Cancers Based on Histology and Cytological FeaturesImmunophenotype- and Genetic Abnormalities-Based Classifications of Leukaemias/Haematopoietic Cancers: Assignment of Human Haematopoietic Malignancy to Their Normal Cell Counterparts; Classification of Leukaemias/Haematopoietic Cancers Using New Technologies; Classification Using Gene Expression Profiling; Classification Using Next Generation Sequencing; Conclusion; References; Chapter 5 Leukaemia/Haematopoietic Cancer-Initiating Cellular Events ; Introduction; Treating Cancer The Relevance of Oncogenes in Human CancerThe Influence of Oncogenes on Their Target Cell; The Cancer Stem Cell Theory; The Nature of the Cancer Cell-of-Origin; Conclusion; References; Chapter 6 Leukaemia/Haematopoietic Cancers and Lineage Commitment ; Introduction; The Concept of Cellular Reprogramming; Experimental Models of Tumoral Reprogramming; Tumoral Reprogramming: Therapeutic Evidences; P53 Is a Barrier to Tumoral Stem Cell Reprogramming; Fidelity of Tumour Lineage Conversion by Oncogenes and Epigenetic Memory; Conclusion; References Chapter 7 The Prospect of New Treatments for Leukaemia and Other Cancers Introduction; Biology and the Treatment of Cancer; The Current Paradigm in Cancer Treatment; A New Paradigm: Cancer Stem Cells; Practical Implications of the CSC Hypothesis; The Nature of Epigenetic Signatures within Cells; Current Use of Epigenetic Modulators to Treat Cancer; Conclusion; References; Authors' Contact Information; Index Bibliography Includes bibliographical references and index Notes Description based on print version record Subject Leukemia. Blood cells. Leukemia Blood Cells HEALTH & FITNESS / Diseases / General MEDICAL / Clinical Medicine MEDICAL / Diseases MEDICAL / Evidence-Based Medicine MEDICAL / Internal Medicine Blood cells Leukemia Form Electronic book Author Sánchez-García, Isidro, author LC no. 2020688021 ISBN 9781634847957 1634847954

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