| Description |
1 online resource (274 pages) |
| Contents |
Intro -- Preface -- Contents -- Contributors -- About the Editor -- Chapter 1: Signaling Pathways of Hyperhomocystenemia and Oxidative Stress -- 1 Introduction -- 2 Cofactors for Re-Methylation and Trans-Sulfuration Pathways -- 2.1 Folate -- 2.2 Vitamin B12 -- 2.3 Vitamin B6 -- 3 Hyperhomocysteinemia and Oxidative Stress -- 4 Conclusion -- References -- Chapter 2: Hyperhomocysteinemia and Cancer: The Role of Natural Products and Nutritional Interventions -- 1 Introduction -- 2 Biosynthesis of Homocysteine -- 3 Metabolism of Homocysteine -- 3.1 Remethylation -- 3.2 Transsulfuration |
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4 Hyperhomocysteinemia Induction -- 4.1 Genetic Enzymatic Defects -- 4.2 Absence/Inadequate Amounts of Certain Cofactors -- 4.3 Excessive Methionine Consumption -- 5 Diseases Associated with Hyperhomocysteinemia -- 5.1 Chronic Renal Failure -- 5.2 Hypothyroidism -- 5.3 Anemia -- 5.4 Malignant Tumors -- 5.5 Medications -- 6 Hyperhomocysteinemia and Cancer -- 7 Hyperhomocysteinemia Management Using Natural Products and Diet -- 8 Conclusion -- References -- Chapter 3: Anti-inflammatory Role of Anthocyanins in the Prevention of Hyperhomocysteinemia-Mediated Cardiometabolic Diseases -- 1 Introduction |
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2 Inflammation -- 3 Inflammation and Hyperhomocysteinemia -- 4 Cardiometabolic Diseases and Plant Polyphenols -- 5 Homocysteine and Anthocyanins -- 6 Anthocyanins: The Treasure of Health -- 6.1 Chemical Structure and Chemistry of Anthocyanins -- 6.2 Anthocyanin and Inflammation -- 7 Conclusion -- References -- Chapter 4: Metabolic Role of Hyperhomocysteinemia in the Etiology of Chronic Diseases -- 1 Introduction -- 2 Homocysteine Metabolism -- 3 Hyperhomocysteinemia and Neurological Disorders -- 3.1 Stroke -- 3.2 Mild Cognitive Impairment (MCI), and Dementia -- 3.3 Parkinson's Disease (PD) |
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3.4 Epilepsy -- 4 Hyperhomocysteinemia and Cardiovascular Diseases -- 5 Hyperhomocysteinemia and Cancer -- 6 Conclusion -- References -- Chapter 5: B-Vitamins Attenuates Preliminary Steps of Hyperhomocysteinemia and Colorectal Cancer -- 1 Introduction -- 2 Dietary and Non-dietary Risk Factors for Colorectal Cancer -- 3 B-Vitamins, Glutathione and Colorectal Cancer -- 4 Hyperhomocysteinemia and Colorectal Cancer -- 5 Conclusion -- References -- Chapter 6: Hyperhomocysteinemia, B-Vitamins, and Coronary Artery Disease Risk -- 1 Introduction |
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2 Sulfur Metabolism and Pathogenesis of Coronary Artery Disease -- 3 Hyperhomocysteinemia and Coronary Artery Disease -- 4 B-Vitamins Therapy and CAD -- 5 Conclusion -- References -- Chapter 7: Potential Role of Hyperhomocysteinemia in Prediabetes Etiology and Pathology -- 1 Introduction -- 2 B-vitamins, Oxidative Stress and Prediabetes Risk -- 3 Hyperhomocysteinemia and the Pathogenesis of Prediabetes and Type 2 Diabetes -- 4 Current Research -- 5 Conclusion -- References -- Chapter 8: Genetic Risk Factors in the Development of Hyperhomocysteinemia -- 1 Introduction |
| Summary |
Elevated blood concentrations of homocysteine, B vitamins deficiencies and oxidative stress are etiological factors for many human chronic diseases, yet the etiologic relationship of hyperhomocysteinemia to these disorders remains poorly understood. Clinical trials continue to support the notion that hyperhomocysteinemia is involved in the pathogenesis of oxidative stress and its associated impairment of cellular redox status. Antioxidants, phytochemicals, and bioactive agents are thought to be associated with the reduction of oxidative stress and reducing risk of chronic diseases, yet their role in preventing hyperhomocysteinemia-mediated oxidative stress has not been well covered in the literature. Nutritional Management and Metabolic Aspects and of Hyperhomocysteinemia comprehensively covers the nutritional-based intervention for combating hyperhomocysteinemia-mediated oxidative stress, metabolic regulation of homocysteine-dependent transulfuration and transmethylation pathways, and the identification of novel biomarkers for early diagnosis of hyperhomocysteinemia. The main goal of this text is to address the biochemical and nutritional aspects of hyperhomocysteinemia in relation to increasing risk of chronic diseases, providing insight into the etiology of hyperhomocysteinemia and covering new research on the effective reduction and management of hyperhomocysteinemia-associated chronic diseases. For researchers seeking a singular source for the understanding of the biochemical aspects and nutrition-based combat of hyperhomocysteinemia, its risk factors, preventive measures, and possible treatments currently available, this text provides all of the important needed information in up-to-date and comprehensive form |
| Notes |
2 Dietary Factors Contributed to Hyperhomocysteinemia |
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Print version record |
| Subject |
Blood -- Diseases -- Diet therapy
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Blood -- Diseases -- Nutritional aspects
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Homocysteine.
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Hyperhomocysteinemia -- physiopathology
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Homocysteine
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Hyperhomocysteinemia -- complications
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Homocysteine -- metabolism
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Homocysteine
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Malalties hematològiques.
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Dieta.
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| Genre/Form |
Llibres electrònics.
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| Form |
Electronic book
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| Author |
Waly, Mostafa I., editor
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| ISBN |
9783030578398 |
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3030578399 |
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9783030578404 |
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3030578402 |
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9783030578411 |
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3030578410 |
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