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Book Cover
E-book
Author Athanasiou, K. A. (Kyriacos A.)

Title Articular cartilage tissue engineering / Kyriacos A. Athanasiou, Eric M. Darling, Jerry C. Hu
Published Cham, Switzerland : Springer, ©2010
Online access available from:
Synthesis Digital Library    View Resource Record  

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Description 1 online resource (xi, 168 pages) : color illustrations
Series Synthesis lectures on tissue engineering, 1944-0308 ; #3
Synthesis lectures on tissue engineering ; #3.
Contents 1. Hyaline articular cartilage -- Composition, structure and function of hyaline cartilage -- Biochemical composition -- Structure -- Function -- Articular chondrocytes -- Chapter concepts -- 2. Cartilage aging and pathology: the impetus for tissue engineering -- Cartilage formation -- Chondrocyte condensation and differentiation -- Hypertrophy and ossification -- Aging -- Cartilage injuries -- Osteochondral, chondral defects, and microfractures -- Causes of cartilage injuries -- Repair responses to cartilage injury -- Costs of articular cartilage injuries -- Osteoarthritis -- Osteoarthritic changes in the matrix -- Proliferation, catabolism, and cell death -- Costs of arthritis -- Motivation for tissue engineering -- Chapter concepts -- 3. In vitro tissue engineering of hyaline articular cartilage -- The need for in vitro tissue engineering -- Cell source -- Scaffold design -- Natural scaffolds -- Synthetic scaffolds -- Composite scaffolds -- Scaffoldless -- Bioactive molecules -- Growth factors -- Protein coating and peptide inclusion -- Catabolic and other structure modifying factors -- Mechanical stimulation -- Chapter concepts -- 4. Bioreactors -- Direct compression -- Hydrostatic pressure -- Shear bioreactors -- Contact shear -- Fluid shear -- Perfusion bioreactors -- "Low-shear" bioreactors -- Hybrid bioreactors -- Chapter concepts
Summary Cartilage injuries in children and adolescents are increasingly observed, with roughly 20% of knee injuries in adolescents requiring surgery. In the US alone, costs of osteoarthritis are in excess of $65 billion per year (both medical costs and lost wages). Comorbidities are common with OA and are also costly to manage. Articular cartilage's low friction and high capacity to bear load makes it critical in the movement of one bone against another, and its lack of a sustained natural healing response has necessitated a plethora of therapies. Tissue engineering is an emerging technology at the threshold of translation to clinical use. Replacement cartilage can be constructed in the laboratory to recapitulate the functional requirements of native tissues. This book outlines the biomechanical and biochemical characteristics of articular cartilage in both normal and pathological states, through development and aging. It also provides a historical perspective of past and current cartilage treatments and previous tissue engineering efforts. Methods and standards for evaluating the function of engineered tissues are discussed, and current cartilage products are presented with an analysis on the United States Food and Drug Administration regulatory pathways that products must follow to market. This book was written to serve as a reference for researchers seeking to learn about articular cartilage, for undergraduate and graduate level courses, and as a compendium of articular cartilage tissue engineering design criteria
Bibliography Includes bibliographical references (pages 101-165)
Subject Articular cartilage.
Tissue engineering.
Articular cartilage -- Diseases.
Knee.
Cartilage, Articular
Knee Joint
Knee
Tissue Engineering
MEDICAL -- Allied Health Services -- Medical Technology.
MEDICAL -- Biotechnology.
MEDICAL -- Family & General Practice.
MEDICAL -- Lasers in Medicine.
TECHNOLOGY & ENGINEERING -- Biomedical.
Knee
Articular cartilage
Articular cartilage -- Diseases
Tissue engineering
Form Electronic book
Author Darling, Eric M
Hu, Jerry C
ISBN 9781598298765
1598298763
9783031025785
3031025784