Limit search to available items
Book Cover

Title Biomaterials associated infection : immunological aspects and antimicrobial strategies / T. Fintan Moriarty, Sebastian A.J. Zaat, Henk J. Busscher, editors
Published New York, NY : Springer, [2013]
Online access available from:
Springer eBooks    View Resource Record  


Description 1 online resource : illustrations (some color)
Contents Part 1. The Pathogenesis of Medical Device associated Infection -- Biomaterial-Associated Infection: A Perspective from the Clinic / Werner Zimmerli and Andrej Trampuz -- Staphylococcus epidermidis in Biomaterial-Associated Infections / Dietrich Mack, Angharad P. Davies, Llinos G. Harris, Rose Jeeves and Ben Pascoe, et al. -- Staphylococcal Virulence Factors / Christine Heilmann and Friedrich Götz -- Propionibacterium acnes: An Emerging Pathogen in Biomaterial-Associated Infection / Sheila Patrick and Andrew McDowell -- Bridging the Gap Between In Vitro and In Vivo Evaluation of Biomaterial-Associated Infections / Guruprakash Subbiahdoss, Joana F. da Silva Domingues, Roel Kuijer, Henny C. van der Mei and Henk J. Busscher -- Biomaterial-Dependent Characteristics of the Foreign Body Response and S. epidermidis Biofilm Interactions / James M. Anderson and Jasmine D. Patel -- Dendritic Cell-Biomaterial Interactions: Implications for the Onset and Development of the Foreign Body Response / Antonio S. Sechi and Behnaz Shokouhi -- Tissue Colonization in Biomaterial-Associated Infection / Sebastian A.J. Zaat -- Systemic Treatment Options for Medical Device-Associated Infection / Oscar Murillo, Jaime Lora-Tamayo and Javier Ariza -- Preventive Measures Against Transcutaneous Device Infections / Paul H.S. Kwakman and Sebastian A.J. Zaat -- Infections Associated with Implanted Dental Devices / Georgios N. Belibasakis, Thomas Thurnheer and Nagihan Bostanci -- Animal Models of Orthopedic Implant-Related Infection / Lorenzo Calabro, Cameron Lutton, Ahmed Fouad Seif El Din, R. Geoff Richards and T. Fintan Moriarty
Part 2. Biomaterial-Based Strategies to Reduce Medical Device-Associated Infection -- Antimicrobial Medical Devices in Preclinical Development and Clinical Use / Benjamin D. Brooks, Amanda E. Brooks and David W. Grainger -- Silver Containing Biomaterials / Neil Poulter, Krasimir Vasilev, Stefani S. Griesser and Hans J. Griesser -- Quaternary Ammonium Compounds / J.A. Loontjens -- Anti-adhesive and Antibacterial Polymer Brushes / K.G. Neoh, Z.L. Shi and E.T. Kang
Part 3. Clinical applications, case studies -- Infection in Fracture Fixation: Device Design and Antibiotic Coatings Reduce Infection Rates / Gerhard Schmidmaier, Abhay D. Gahukamble, T. Fintan Moriarty and R. Geoff Richards -- The Indwelling Bladder Catheter: Attempts to Prevent Infection and the Development of Bacterial Biofilms / David Stickler and Roger Feneley -- Antimicrobial-Modified Vascular Catheters / Rabih O. Darouiche -- Topical Antimicrobial-Containing Biomaterials for Peri-Implant Infections in the Oral Cavity / Stefan Renvert and G. Rutger Persson -- Preventive Strategies in VAP: Focus on Silver-Coated Endotracheal Tubes / Marin Kollef
Summary Biomaterials associated infection (BAI) is one of the most common complications associated with implantation of any biomaterial regardless of form or function. These infections usually involve bacterial colonization and biofilm formation on the biomaterial itself, rendering the infection impervious to antimicrobials and host defenses. In addition, it is becoming increasingly clear that infection of the surrounding tissues also plays an important role in BAI, and that the infection may be influenced by the composition and design of the implanted biomaterial. In this book, worldwide leaders in the field address this critical problem in the translation of biomaterials research into clinical practice. The book begins with an emphasis on the latest research in the pathogenesis of BAI from microbiological, immunological, and materials science perspectives. The current state of the art in antimicrobial activation of biomaterials through surface modification and the incorporation of antimicrobial agents is then discussed. In the concluding chapters, successful translation of a selection of antimicrobial technologies from preclinical research into clinical use is described alongside a discussion of the utility of these devices and perspectives for future development. This book is essential reading for researchers and clinicians who are interested in understanding the fundamentals of BAI, the latest in antimicrobial materials research, and the state of the art in clinically available antimicrobial containing medical devices. Provides a clinical perspective to set research directionsSummarizes the pathogenicity of the most common bacterial species isolated in BAICovers both biofilms and tissue reservoirs as modes of infectionPresents state-of-the-art issues of immune function in the vicinity of implanted biomaterialsDescribes the latest technologies for antimicrobial activation of biomaterials
Analysis Immunology
Biomedical engineering
Materials Science
Bibliography Includes bibliographical references and index
Subject Biomedical materials -- Biocompatibility.
Biomedical and Dental Materials -- contraindications.
Form Electronic book
Author Moriarty, T. Fintan.
Zaat, Sebastian A. J.
Busscher, H. J.
ISBN 1461410312 (electronic bk.)
9781461410317 (electronic bk.)