Preface; Contents; Contributors; Part I General Aspects of Aging; Protein Redox-Regulation Mechanisms in Aging; Nitrosative Stress in Aging -- Its Importance and Biological Implications in NF-B Signaling; Intervention with Multiple Micronutrients Including Dietaryand Endogenous Antioxidants for Healthy Aging; Advanced Glycation End Products, RAGE, and Aging; Sirtuins and Mammalian Aging; Estrogenic Modulation of Longevity by Inductionof Antioxidant Enzymes; Mitochondrial Respiratory Function Decline in Agingand Life-Span Extension by Caloric Restriction
Summary
Features that characterize the aging process include the gradual accumulation of cell damage after prolonged exposure to oxidative and inflammatory events over a lifetime. In addition to the accretion of lesions, the intrinsic levels of pro-oxidant and aberrant immune responses are elevated with age. These adverse events are often further enhanced by the chronic and slow progressing diseases that characterize the senescent brain and cardiovascular system. The incidence of some disorders such as Alzheimer's disease and vascular diseases are sufficiently prevalent in the extreme elderly that the
