BIOLOGIC MARKERS IN URINARY TOXICOLOGY -- COPYRIGHT -- OTHER RECENT REPORTS OF THE BOARD ON ENVIRONMENTAL STUDIES AND TOXICOLOGY -- PREFACE -- CONTENTS -- EXECUTIVE SUMMARY -- EFFECTS OF TOXIC EXPOSURE OF THE URINARY TRACT -- BIOLOGIC MARKERS OF SUSCEPTIBILITY AND EXPOSURE -- BIOLOGIC MARKERS OF EFFECT -- BIOLOGIC MARKERS IN EXTRAPOLATION -- NEW TECHNOLOGIES -- THE SUBCOMMITTEE'S RECOMMENDATIONS -- General -- The Kidney -- The Bladder -- The Prostate -- Biologic Markers of Exposure and Susceptibility -- Biologic Markers of Effect
Use of Biologic Markers in ExtrapolationNew Technologies -- 1 INTRODUCTION -- BIOLOGIC MARKERS -- Markers of Exposure -- Markers of Effect -- Markers of Susceptibility -- VALIDITY OF BIOLOGIC MARKERS -- ETHICAL ISSUES -- STRUCTURE OF THE REPORT -- 2 TOXIC EXPOSURE OF THE URINARY TRACT -- THE URINARY TRACT -- Renal Blood Flow -- Glomerular Filtration -- Tubular Reabsorption and Secretion -- Hormonal Action -- MECHANISMS OF RENAL TOXICITY -- Susceptibility to Injury -- Direct Toxic Effects -- Renal Vascular Injury -- Glomerular Capillary Injury
Renal Tubular-Cell InjuryIndirect Toxic Effects -- Immunopathologic Mechanisms -- Xenobiotic Metabolism -- Necrosis and Apoptosis -- HOST FACTORS IN RENAL TOXICITY -- Changes with Renal Growth and Aging -- Changes with Diet -- Influence of Pre-existing Renal Function -- Nephron Number at Birth -- Acute Renal Disease -- Chronic Renal Disease -- Physiologic Responses to Renal Injury -- Physiologic Changes with Compensatory Hypertrophy -- Factors Associated with Progressive Low of Renal Function -- CLINICAL EFFECTS OF CHEMICAL EXPOSURE ON THE KIDNEY
Acute Renal FailureTubulointestitial Nephritis -- Chronic Glomerulonephritis -- Rapidly Progressive Glomerulonephritis -- Nephrotic Syndrome -- Hypertension -- CANCER OF THE BLADDER, KIDNEY, AND PROSTATE -- Tumor-Suppressor Genes, Oncogenes, and Growth Factors -- Cancer of the Bladder -- Cancer of the Kidney -- Cancer of the Prostate -- Interstitial Cystitis -- ANIMAL MODELS OF INTERSTITIAL CYSTITIS -- SUMMARY -- 3 BIOLOGIC MARKETS OF SUSCEPTIBILITY AND EXPOSURE -- POPULATIONS AT RISK -- Hereditary Susceptibility to Nephrotoxicity -- Nutrition
Socioeconomic FactorsAge -- Coexisting Chronic Disease -- Addictive Behavior and Recreational Drug Use -- Occupational or Environmental Exposure -- MARKERS OF SUSCEPTIBILITY -- Modifying Factors of Susceptibility -- Parenchymal Renal Disease -- Cytochrome P-450-Dependent Activation of Nephrotoxicants -- Prostaglandin H Synthase-Dependent Activation of Nephrotoxicants -- Glutathione-Dependent Activation of Nephrotoxicants -- Extrarenal Conjugation and Interorgan Metabolism
Notes
""GSH Conjugation of Halogenated Alkanes and Alkenes by Cytosolic and Microsomal GSH S-Transferases""
