Contributors; 1 Introduction to Sumoylation; 1.1 The SUMO Proteins; 1.2 The Enzymology of Sumoylation; 1.3 Sumoylation Functions; 1.4 Conclusion; References; Part I Molecular Functions; 2 SUMO Modification and Transcriptional Regulation; 3 Emerging Roles for SUMO in mRNA Processing and Metabolism; 4 SUMO and Chromatin Remodelling; 5 Functions of SUMO in the Maintenance of Genome Stability; 6 SUMO and Nucleocytoplasmic Transport; 7 SUMO Modification of Ion Channels; 8 The Roles of SUMO in Metabolic Regulation; Part II Cell Growth Regulation; 9 The SUMO Pathway in Mitosis
Summary
A small cellular protein of 12 kDa was co-discovered and termed Small Ubiquitin-like Modifier (SUMO). Sumoylation is a post-translational modification that utilizes SUMO as the modifier group covalently attached to target substrates. This book examines the part sumoylation plays in critical cellular processes such as mitosis, and meiosis
