| Description |
1 online resource (vii, 184 pages) : illustrations |
| Series |
Progress in experimental tumor research, 0079-6263 ; v. 36 |
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Progress in experimental tumor research ; v. 36. 0079-6263
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| Contents |
Basic Principles of Gene Transfer in Hematopoietic Stem Cells / M. Sadelain, C. May and S. Rivella / [and others] -- Optimizing Conditions for Gene Transfer into Human Hematopoietic Cells / M.A.S. Moore and K.L. MacKenzie -- Transfer of the MDR-1 Gene into Hematopoietic Cells / A. Bank, M. Ward and C. Hesdorffer -- Ove Hematopoietic Cell Tolerance to Alkylating Agents / B.M. Davis, O.N. Koc and J.S. Reese / [et al.] -- Use of Variants of Dihydrofolate Reductase in Gene Transfer to Produce Resistance to Methotrexate and Trimetrexate / J.R. Bertino, S.C. Zhao and S. Mineishi / [et al.] -- Augmentation of Methotrexate Resistance with Coexpression of Metabolically Related Genes / S. Mineishi -- Protection of Bone Marrow Cells from Toxicity of Chemotherapeutic Agents Targeted toward Thymidylate Synthase by Transfer of Mutant Forms of Human Thymidylate Synthase cDNA / D. Banerjee, Y. Tong and X. Liu-Chen / [et al.] -- Dihydropyrimidine Dehydrogenase and Resistance to 5-Fluorouracil / R.B. Diasio -- Chemoprotection against Cytosine Nucleoside Analogs Using the Human Cytidine Deaminase Gene / N. Eliopoulos, C. Beausejour and R.L. Momparler -- In vivo Selection of Hematopoietic Stem Cells Transduced with DHFR-Expressing Retroviral Vectors / B.P. Sorrentino, J.A. Allay and R.L. Blakley -- In vivo Selection of Genetically Modified Bone Marrow Cells / C.A. Blau -- Gene Transfer in the Nonmyeloablated Host / P.J. Quesenberry and P.S. Becker |
| Summary |
Authored by experts in the field, this volume provides a comprehensive review of the problems and opportunities in gene therapy focusing on the use of various drug resistance genes to provide protection of hematopoietic cells against drug toxicity. General topics include basic principles of gene transfer, optimizing conditions for gene transfer in hematopoietic cells, and gene transfer in the nonmyeloablated host. Specific chapters describe constructions and preclinical studies of specific genes that impart resistance to anticancer drugs when expressed in hematopoietic cells including MDR-1, mutated forms of human methylguanine-DNA-methyltranferase, mutant forms of dihydrofolate reductase and thymidylate synthase, dihydropyrimidine dehydrogenase and cytidine deaminase. For successful transfer of drug resistance genes, the possibility that they may be used as selectable markers and that marrow ablation may not be required are important considerations. This book is especially timely, as clinical trials with these drug resistance genes are expected to increase markedly in the next few years. It should appeal to all interested in stem cell biology and gene therapy, as well as clinicians who look forward to using this technology in their practice |
| Bibliography |
Includes bibliographical references and indexes |
| Notes |
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL |
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digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL |
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Print version record |
| Subject |
Cancer -- Chemotherapy -- Complications -- Gene therapy
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Hematopoietic stem cells.
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Drug resistance in cancer cells.
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Transduction.
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Genetic transformation.
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Gene therapy.
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Hematopoietic Stem Cells
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Drug Resistance, Neoplasm
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Transduction, Genetic
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Drug Resistance, Neoplasm -- genetics
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Genetic Therapy
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Gene Transfer Techniques
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Gene therapy
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Drug resistance in cancer cells
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Genetic transformation
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Hematopoietic stem cells
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Transduction
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Blutstammzelle -- Transduktion -- Arzneimittelresistenz -- Resistenzgen -- Aufsatzsammlung.
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Transduktion -- Blutstammzelle -- Arzneimittelresistenz -- Resistenzgen -- Aufsatzsammlung.
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Arzneimittelresistenz -- Resistenzgen -- Blutstammzelle -- Transduktion -- Aufsatzsammlung.
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Resistenzgen -- Arzneimittelresistenz -- Blutstammzelle -- Transduktion -- Aufsatzsammlung.
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Thérapie génique.
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Cellules souches hématopoïétiques.
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Résistance aux médicaments antinéoplasiques.
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Techniques de transfert de gène.
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Thérapie génique.
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Cancer -- Chimiothérapie -- Complications.
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Cellules souches hématopoïétiques.
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Cellules cancéreuses -- Résistance aux médicaments.
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Transduction.
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Cancer -- Thérapie génique.
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Transformation génétique.
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| Form |
Electronic book
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| Author |
Bertino, Joseph R
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| ISBN |
9783318003970 |
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3318003972 |
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