| Description |
1 online resource (xiv, 184 pages) : illustrations |
| Contents |
Cover -- Contents -- About the Authors -- Abbreviations -- 1 Historical Background and Book Aim -- 1.1 Historical Background -- 1.2 Book Aim and Plan -- 2 The Heart Complexity -- The Intrinsic Function (Intrinsic Regulation of Heart Rate and Mechanics) -- 2.1 Preamble -- 2.2 Heart Physiology: the Classical View -- 2.3 Neural Control of the Heart:Cardiac Receptors, Afferent/Efferent Neural Pathways, Baro- and Chemoreceptive Feedback -- 2.3.1 Premises on the Neuro-Humoral Control of the Cardiovascular System -- 2.3.2 Autonomic Control of Heart Rate -- 2.3.3 Afferent Stimuli -- 2.3.4 Efferent Neural Connections -- 2.3.5 Spinal Cord -- 2.3.6 Medullary Centers -- 2.3.7 Supramedullary Control -- 2.4 The Integrated Neuro-Hormonal Response: Short- and Long-Term Response -- 2.5 Heart Physiology:What is New? -- 3 The Cardiac Natriuretic Hormone System -- 3.1 Chemical Structure and Gene Evolution of Cardiac Natriuretic Hormones -- 3.2 Genes Encoding for Cardiac Natriuretic Hormones -- 3.3 Regulation of Production/Secretion of ANP and BNP in Cardiac Tissue -- 3.4 Biological Action of CNH -- 3.5 Natriuretic Peptide Receptors and Intracellular Second Messenger Signaling -- 3.5.1 Genes Encoding for NPRs -- 3.5.2 Biological Function of NPRs -- 3.6 Metabolic Pathways and Circulating Levels of CNH -- 3.6.1 ANP Metabolism -- 3.6.2 BNP Metabolism -- 3.7 CNH System in Fetal Heart and Circulation -- 3.8 CNH Genes and Cardiovascular Diseases -- 3.9 An Integrated Neuro-Hormonal System Regulates Vascular Function -- 3.10 Summary and Conclusion -- 4 Cardiac Natriuretic Hormones as Markers of Cardiovascular Disease: Methodological Aspects -- 4.1 General Considerations -- 4.2 Determination of ANP and NT-proANP -- 4.2.1 Competitive Immunoassay Methods for ANP -- 4.2.2 Non-Competitive Immunoassay Methods for ANP -- 4.2.3 Determination of NT-proANP -- 4.3 Determination of BNP and NT-proBNP -- 4.3.1 First-Generation (Manual) BNP Assays -- 4.3.2 Second-Generation (Automated) BNP Assays -- 4.3.3 Determination of NT-proBNP -- 4.3.4 Specificity of BNP/NT-proBNP Assays -- 4.3.5 Quality Specifications for BNP/NT-proBNP Assays -- 4.4 Determination of Other Natriuretic Peptides (CNP, DNP, and Urodilatin) -- 4.5 Summary and Perspectives -- 5 Clinical Considerations and Applications in Cardiac Diseases -- 5.1 Circulating Levels of Cardiac Natriuretic Hormones: Physiological Considerations and Clinical Interpretation -- 5.1.1 Influence of Age and Gender -- 5.1.2 Comparison between the CNH Assay and that of CNH-Related Pro-Hormone Peptides -- 5.1.3 Resistance to the Biological Action of CNH -- 5.1.4 Diagnostic Accuracy of CNH Assay in Plasma from Patients with Cardiac Diseases -- 5.1.5 Biological Variation of Plasma BNP: a Problem or a Clinical Resource? -- 5.2 CNH Assay as Diagnostic and Prognostic Tool in Cardiac Diseases -- 5.2.1 Use of CNH Assay in the Screening and Classification of Patients with Cardiac Dysfunction -- 5.2.2 Diagnostic Accuracy of CNH Assay in Asymptomatic, Mild Ventricular Systolic Dysfunction -- 5.2.3 Diagnostic |
| Summary |
The rapid knowledge in the field of neuro-humoral regulation of cardiovascular pathophysiology is changing the picture of current diagnosis and treatment of cardiac patients. The emerging conceptual revolutionary idea is that heart acts not as a pump, merely, but as a ""gland"", that is as a regulator of circulatory homeostasis and salt-water balance. Cardiovascular pathophysiology has to be written, indeed, on this basis: this physiology textbook gives an up-to-date description of the complexity and novelty of actual knowledge, with all its potential clinical implications |
| Analysis |
geneeskunde |
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medicine |
|
volksgezondheid |
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public health |
|
endocrinologie |
|
endocrinology |
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pathologie |
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pathology |
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cardiologie |
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cardiology |
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Medicine (General) |
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Geneeskunde (algemeen) |
| Bibliography |
Includes bibliographical references |
| Notes |
Print version record |
| In |
OhioLINK electronic book center |
|
SpringerLink |
| Subject |
Atrial natriuretic peptides.
|
|
Atrial Natriuretic Factor
|
|
MEDICAL -- Biochemistry.
|
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Atrial natriuretic peptides.
|
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Atrial natriuretic peptides
|
| Form |
Electronic book
|
| Author |
Clerico, Aldo.
|
|
Emdin, Michele.
|
| ISBN |
9788847004986 |
|
8847004985 |
|
9788847004979 |
|
8847004977 |
|
