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Author Evsyukova, Helen V.

Title Platelets and aspirin-induced asthma : pathogenesis and melatonin / Helen V. Evsyukova ; edited by M. Joseph, former director of research from Centre National de la Recherce Scientifique, Institut Pasteur de Lille, France
Published Amsterdam : Elsevier/Academic Press, 2014


Description 1 online resource (155 pages) : illustrations
Contents Front Cover; Platelets and Aspirin-Induced Asthma; Copyright Page; Contents; List of Abbreviations; About the Author; Foreword; Introduction; 1 Clinical Picture of Aspirin-Induced Asthma (AIA); 1.1 Clinical Risk Factors and Course of Aspirin-Induced Asthma; 1.2 Peculiarities of Pulmonary Function, Laboratory Data, and Pulmonary Circulation State in AIA Patients; 2 Diffuse Neuroimmunoendocrine System (DNIES) and its Role in the Human Body; 2.1 Definition; 2.2 Melatonin (MT) as DNIES Hormone and its Role in Regulating the Activity of the Organism's Functional Systems
2.2.1 MT Synthesis and Metabolism in the Organism2.2.2 The Role of MT in Regulation of Biological Rhythms; 2.2.3 MT as an Endogenous Antioxidant; 2.2.4 Role of MT in Regulation of Platelet-Vessel Hemostasis; 2.2.5 MT's Effect on Nitric Oxide Production in Organism; 2.2.6 The Role of MT in the Regulation of Arachidonic Acid (AA) Metabolism; 3 State of DNIES in Aspirin-Induced Asthma; 3.1 MT Production in Patients with AIA; 3.2 Platelet-Vessel Hemostasis in Patients with AIA; 3.2.1 Platelet Functional Activity in Patients with AIA
3.2.2 Peculiarities of Nitric Oxide,Thromboxane and Prostacyclin Production in AIA3.3 Adrenal Glucocorticoid's Function in Patients with AIA; 3.4 Peculiarities of Immune System in Patients with AIA; 3.5 AA Metabolism in Patients with AIA; 4 Pathogenesis of Aspirin-Induced Asthma; Conclusion; References
Summary Platelets and Aspirin-Induced Asthma is the first book to be published that reflects research conducted on aspirin-induced asthma pathogenesis. It is examined through positions of neuroimmunoendocrine interactions in organism. The Melatonin hormone plays a key role, being the regulator and coordinator of complicated and interrelated biological processes. This new concept of aspirin-induced asthma pathogenesis suggests new methods for treatment of this disease by means of correcting the melatonin content in the patient's organism. Investigations into the mechanisms of aspirin-induced asthma
Bibliography Includes bibliographical references
Notes Online resource; title from PDF title page (ebrary, viewed November 14, 2013)
Subject Asthma -- Pathophysiology
Asthma -- Etiology
Blood platelets.
Aspirin -- Side effects
Asthma, Aspirin-Induced
Blood Platelets -- metabolism
Melatonin -- physiology
Aspirin -- adverse effects
Neurosecretory Systems -- physiopathology
Blood Platelets
FAMILY & RELATIONSHIPS -- Life Stages -- General.
PSYCHOLOGY -- Developmental -- General.
PSYCHOLOGY -- Developmental -- Lifespan Development.
PSYCHOLOGY -- General.
Aspirin -- Side effects
Asthma -- Etiology
Asthma -- Pathophysiology
Blood platelets
Genre/Form Electronic book
Form Electronic book
Author Joseph, M., editor
LC no. 2013370367
ISBN 9780128001035