| Description |
1 online resource (xiv, 354 pages) : illustrations (some color) |
| Series |
Advances in Experimental Medicine and Biology, 0065-2598 ; 795 |
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Advances in experimental medicine and biology ; v. 795. 0065-2598
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| Contents |
Part I. The Spectrum of Asthma: An Introduction -- Introduction to Asthma and Phenotyping / Regina A. Pillai and William J. Calhoun -- Epidemiology of Asthma: Prevalence and Burden of Disease / Sharon Croisant -- Heterogeneity of Asthma in Society / Rohit Divekar and William J. Calhoun -- Inhaled Environmental Allergens and Toxicants as Determinants of the Asthma Phenotype / Kristin Sokol, Sanjiv Sur and Bill T. Ameredes -- Current Clinical Diagnostic Tests for Asthma / Shiwan Shah and Gulshan Sharma -- Management of Asthma: The Current US and European Guidelines / Ashwini P. Reddy and Meera R. Gupta -- Community-Based Interventions in Asthma / Sharon Petronella Croisant and Lauren Scott -- Heterogeneity of Response to Therapy / William J. Calhoun -- Part II. Genetics and Genomics in Asthma -- Introduction to Genetics and Genomics in Asthma: Genetics of Asthma / Rasika Ann Mathias -- Gene Expression Profiling in Asthma / Joanne Sordillo and Benjamin A. Raby -- Asthma Epigenetics / Muhammad T. Salam -- Part III. Proteomics, Metabolomics, and Systems Biology of Asthma -- Overview / John E. Wiktorowicz -- Metabolomics in Asthma / Bruce A. Luxon -- Proteomic Analysis of the Asthmatic Airway / John E. Wiktorowicz and Mohammad Jamaluddin -- Measurement of the Innate Immune Response in the Airway / Allan R. Brasier and Yingxin Zhao -- Functional Proteomics for the Characterization of Impaired Cellular Responses to Glucocorticoids in Asthma / Konrad Pazdrak and Alexander Kurosky -- Part IV. Modeling Complex Data in Asthma -- Analysis and Predictive Modeling of Asthma Phenotypes / Allan R. Brasier and Hyunsu Ju -- The Role of Visual Analytics in Asthma Phenotyping and Biomarker Discovery / Suresh K. Bhavnani, Justin Drake and Rohit Divekar -- Part V. Biobehavioral Determinants in Asthma -- Central Nervous System Influences in Asthma / Joel N. Kline and Robert M. Rose -- Asthma, Culture, and Cultural Analysis: Continuing Challenges / Mike Fortun, Kim Fortun, Brandon Costelloe-Kuehn, Tahereh Saheb [and 3 others] -- Part VI. Conclusions and Future Directions -- Conclusions and Future Directions / William J. Calhoun and Allan R. Brasier |
| Summary |
Asthma is a chronic relapsing airways disease that represents a major public health problem worldwide. Intermittent exacerbations are provoked by airway mucosal exposure to pro-inflammatory stimuli, with RNA viral infections or inhaled allergens representing the two most common precipitants. In this setting, inducible signaling pathways the airway mucosa play a central role in the initiation of airway inflammation through production of antimicrobial peptides (defensins), cytokines, chemokines and arachidonic acid metabolites that coordinate the complex processes of vascular permeability, cellular recruitment, mucous hyper-secretion, bronchial constriction and tissue remodeling. These signals also are responsible for leukocytic infiltration into the submucosa, T helper-lymphocyte skewing, and allergic sensitization. Currently, it is well appreciated that asthma is a heterogeneous in terms of onset, exacerbants, severity, and treatment response. Current asthma classification methods are largely descriptive and focus on a single aspect or dimension of the disease. An active area of investigation on how to collect, use and visualize multidimensional profiling in asthma. This book will overview multidimensional profiling strategies and visualization approaches for phenotyping asthma. As an outcome, this work will facilitate the understanding of disease etiology, prognosis and/or therapeutic intervention |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed October 28, 2013) |
| Subject |
Asthma.
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Asthma -- Etiology
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Asthma
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Asthma
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Asthma -- Etiology
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| Form |
Electronic book
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| Author |
Brasier, Allan R., editor
|
| ISBN |
9781461486039 |
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1461486033 |
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1461486025 |
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9781461486022 |
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