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Title NSAIDs and aspirin : recent advances and implications for clinical management / Angel Lanas, editor
Published [Switzerland] : Springer, 2016


Description 1 online resource
Contents Preface; Acknowledgments; Contents; Contributors; Abbreviations; Part I: Pharmacology and Mechanisms; 1: Chemistry, Pharmacodynamics, and Pharmacokinetics of NSAIDs; Introduction; Chemistry; Pharmacodynamics; Nonselective vs. Isoform-Specific COX Inhibitors; Structural Factors; Kinetic Factors; Allosteric Factors; COX-Independent Actions; Pharmacokinetics; Absorption; Distribution; Elimination; References; 2: Principles, Mechanisms of Action, and Future Prospects of Anti-inflammatory Drugs; Introduction; Eicosanoids; COX Pathway; COX-2; COX Inhibitors; Selective COX-2 Inhibitors (COXIBs)
MPGES-1 InhibitorsAgonists and Antagonists of Prostanoid Receptors; Cyclopentenone PGs; Other Approaches; Drugs Acting on the 5-LOX Pathway; Dual COX-2/5-LO Inhibitors; NSAIDs Releasing Nitric Oxide (NO) or Hydrogen Sulfide (H2S); Aspirin-Triggered 15-Epi-lipoxins; Conclusions; References; Part II: Clinical Effects and Drug Safety; 3: Efficacy of NSAIDs in the Treatment of Rheumatic Diseases; Introduction; Osteoarthritis; Rheumatoid Arthritis; Ankylosing Spondylitis; Acute Gout; Conclusion; References
4: Adverse Effects of NSAIDs in the Gastrointestinal Tract: Risk Factors of Gastrointestinal Toxicity with NSAIDsIntroduction; Epidemiology; Pathogenesis; Gastrointestinal Toxicity of NSAIDS; Upper Gastrointestinal Tract; Lower Gastrointestinal Tract; Other Gastrointestinal Symptoms; Risk Factors for Gastrointestinal Toxicity; Concomitant Use of Aspirin and Another NSAID; Concomitant Use with Anticoagulants; Concomitant Use with Corticosteroids; Helicobacter pylori Infection; Past History of Complicated Ulcers; Stratification by Gastrointestinal Risks
Strategies to Reduce NSAID-Associated UlcersHistamine-2 Receptor Antagonist; Misoprostol; Proton-Pump Inhibitors; COX-2 Inhibitors; Cardiovascular Risks of NSAIDS; Balancing Cardiovascular and Gastrointestinal Risks; Conclusions; References; 5: Adverse Effects of Nonsteroidal Anti-inflammatory Drugs on the Cardiovascular System; The Need for NSAID Therapy in Patients with Cardiovascular Disease; Cardiovascular Adverse Effects of NSAIDs; Myocardial Infarction; Randomized Trials and Meta-analyses Focused on Cardiovascular Events; Meta-analyses; Time Dependence of NSAID-Associated CV Risk
CV Risk of NSAID Use After First-Time Myocardial InfarctionCV Risk of NSAIDs in Special Patient Populations; Inflammatory Arthritides; Osteoarthritis; Diabetes Mellitus; CV Adverse Effects of NSAIDs: Is There a Genetic Predisposition?; CV Adverse Effects of NSAIDs: Is COX-2-Mediated Immunomodulation Responsible?; Stroke; Non-ischemic CV Adverse Effects of NSAIDs; Congestive Heart Failure; Atrial Fibrillation; Effects on Renal Function and Blood Pressure; NSAID-Induced Fluid and Electrolyte Disturbances; Peripheral Edema
Summary This volume is a state-of-the art resource on the recent advances and clinical management of NSAIDs and aspirin. The text provides a thorough overview of NSAIDS and aspirin, reviewing such topics as pharmacology and mechanisms, clinical effects, and the safety and efficacy of these drugs. It also focuses on the effect of the drugs on the cardiovascular system and in the prevention of GI cancer. Practical recommendations for a safe prescription of NSAIDs are also included. Written by experts in the field, NSAIDs and Aspirin: Recent Advances and Implications for Clinical Management is a comprehensive text of great value to gastroenterologists, rheumatologists, cardiologists, oncologists, orthopedists, trauma and internal medicine specialists
Bibliography Includes bibliographical references and index
Subject Nonsteroidal anti-inflammatory agents.
Anti-Inflammatory Agents, Non-Steroidal
Cardiovascular medicine.
MEDICAL -- Pharmacology.
Nonsteroidal anti-inflammatory agents.
Form Electronic book
Author Lanas, A. (Ángel)
ISBN 9783319338897