| Description |
1 online resource (xxvi, 1332 pages) : illustrations (chiefly color) |
| Contents |
Structural and molecular bases of ion channel function. Voltage-gated sodium channels and electrical excitability of the heart -- Calcium channels in the heart -- Voltage-regulated potassium channels -- Structural and molecular bases of cardiac inward rectifier potassium channel function -- Mammalian calcium pumps in health and disease -- Structural and molecular bases of sarcoplasmic reticulum ion channel function -- Structural and molecular bases of mitochondrial ion channel function -- Molecular organization, gating, and function of gap junction channels -- Biophysics of cardiac ion channel function. Biophysics of normal and abnormal cardiac sodium channel function -- Regulation of cardiac calcium channels -- KCNQ₁/KCNE₁ macromolecular signaling complex: channel microdomains and human disease -- Structural determinants and biophysical properties of hERG₁ channel gating -- Molecular regulation of cardiac inward rectifier potassium channels by pharmacologic agents -- Cardiac stretch-activated channels and mechano-electric coupling -- Biophysical properties of gap junctions -- Excitation-contraction coupling -- Intermolecular interactions and cardiomyocyte electrical function. Ion channel trafficking in the heart -- Macromolecular complexes and regulation of the sodium channel Nav1.5 -- Calmodulin and CamKII as Ca ² switches for cardiac ion channels -- Macromolecular complexes and cardiac potassium channels -- Reciprocity of cardiac sodium and potassium channels in the control of excitability and arrhythmias -- The intercalated disc: a molecular network that integrates electrical coupling, intercellular adhesion, and cell excitability -- Scaffolding proteins and ion channel diseases -- Epigenetics in cardiac rhythm diseases -- Cell biology of cardiac impulse initiation and propagation. Cardiac impulse is initiated by a coupled system of membrane ion channels and Ca²+ cycling proteins -- Biological pacing -- Intercellular communication and impulse propagation -- Mechanisms of atrioventricular nodal excitability and propagation -- Cell biology of the specialized cardiac conduction system -- Cardiac fibroblasts and arrhythmogenesis -- Models of cardiac excitation. Ionic mechanisms of atrial action potentials -- Models of the ventricular action potential in health and disease -- Calcium signaling in cardiomyocyte models with realistic geometries -- Theory of rotors and arrhythmias -- Supraventricular arrhythmias in a realistic 3D model of the human atria -- Cardiac electromechanical models -- Neural control of cardiac electrical activity. CaV1.2 and [beta]-adrenergic regulation of cardiac function -- Cholinergic and constitutive regulation of atrial potassium channel -- Pulmonary vein ganglia and the neural regulation of the heart rate -- Neural activity and atrial tachyarrhythmias -- Sympathetic innervation, denervation, and cardiac arrhythmias -- Arrhythmia mechanisms. Dominant frequency and the mechanisms of initiation and maintenance of atrial fibrillation -- Rotors in human atrial fibrillation -- Atrial ischemia and fibrillation -- The molecular pathophysiology of atrial fibrillation -- Myofibroblasts, cytokines, and persistent atrial fibrillation -- Role of the autonomic nervous system in atrial fibrillation -- Mechanisms of ventricular tachycardia and fibrillation -- Molecular genetics and pharmacogenomics. Genetics of atrial fibrillation -- Mechanisms in heritable sodium channel diseases -- Inheritable potassium channel disease -- Genetics and cellular mechanisms of the J wave syndromes -- Inheritable phenotypes associated with altered intracellular calcium regulation -- Pharmacologic, genetic and cell therapy of ion channel dysfunction. Pharmacologic bases of antiarrhythmic therapy -- Pharmacogenomics of cardiac arrhythmias -- Optogenetic control of heart muscle -- Cell therapy and regenerative electrophysiology -- Diagnostic evaluation. Assessment of the patient with a cardiac arrhythmia -- Differential diagnosis of narrow and wide complex tachycardias -- Mapping and imaging -- CT and MRI for electrophysiology -- Intracardiac echocardiography for electrophysiology -- Exercise-induced arrhythmias -- Cardiac monitoring: short- and long-term recording -- Electrocardiographic imaging in patients with acute coronary syndrome |
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Head-up tilt table testing -- Autonomic testing and cardiac risk -- Monophasic action potential recording -- T wave alternans -- Noninvasive electrocardiographic imaging of human ventricular arrhythmias and electrophysiological substrate -- Genetic testing -- Supraventricular tachyarrhythmias: mechanisms, clinical features, and management. Sinus node abnormalities -- Atrial tachycardia -- Typical and atypical atrial flutter: mapping and ablation -- Atrial fibrillation: paroxysmal, persistent, and permanent -- Preexcitation, atrioventricular reentry, and variants -- Electrophysiological characteristics of atrioventricular nodal reentrant tachycardia -- Atrial tachyarrhythmias in adults with congenital heart disease -- Junctional tachycardia -- Ventricular tachyarrhythmias: mechanisms, clinical features, and management. Premature ventricular complexes -- Outflow tract ventricular tachyarrhythmias: mechanisms, clinical features, and management -- Fascicular ventricular arrhythmias -- Bundle branch reentry tachycardia -- Ischemic heart disease -- Ventricular tachycardia in patients with dilated cardiomyopathy -- Ventricular arrhythmias in hypertrophic cardiomyopathy -- Ventricular tachycardias in arrhythmogenic right ventricular dysplasia/cardiomyopathy -- VTs in catecholaminergic cardiomyopathy (catecholaminergic polymorphic ventricular tachycardia) -- Ventricular arrhythmias in heart failure -- Ventricular tachycardia in noncompaction cardiomyopathy -- Ventricular arrhythmias in Takotsubo cardiomyopathy -- Brugada syndrome 1992-2012: twenty years of scientific progress -- Long and short QT syndromes -- Andersen-Tawil syndrome -- Timothy syndrome -- J wave syndromes -- Idiopathic ventricular fibrillation -- Sudden infant death syndrome -- Sudden cardiac death in adults -- Arrhythmias in patients with neurologic disorders -- Drug-induced ventricular tachycardia -- Syncope and AV block. Syncope -- Postural orthostatic tachycardia syndrome -- Progressive conduction system disease -- Atrioventricular block -- Arrhythmias in special populations. Sex differences in arrhythmias -- Sudden cardiac deaths in athletes, including commotio cordis -- Arrhythmias in pediatric population -- Sleep-disordered breathing and arrhythmias -- Pharmacologic therapy. Standard antiarrhythmic drugs -- New antiarrhythmic drugs and new concepts for old drugs -- Impact of nontraditional antiarrhythmic drugs on sudden cardiac death -- Prevention of stroke in patients with atrial fibrillation -- Electrical therapy. Implantable cardioverter defibrillators: technical aspects -- Implantable cardioverter defibrillator: clinical aspects -- Implantable pacemakers -- Cardiac resynchronization therapy -- Newer applications of pacemakers -- Catheter ablation: technical aspects -- Catheter ablation: clinical aspects -- Ablation for atrial fibrillation -- Ablation of supraventricular tachyarrhythmias -- Catheter ablation for ventricular tachycardia in patients with structural heart disease -- Special ablation approaches: epicardial, other -- Ablation in pediatrics -- Catheter ablation in congenital heart disease -- Surgery for arrhythmias. Surgery for atrial fibrillation and other SVTs -- Surgery for ventricular arrhythmias -- Vagal stimulation for heart failure -- New approaches. Spinal cord stimulation for heart failure and arrhythmias -- Left atrial occluders/isolation |
| Summary |
Cardiac Electrophysiology: From Cell to Bedside puts the latest knowledge in this subspecialty at your fingertips, giving you a well-rounded, expert grasp of every cardiac electrophysiology issue that affects your patient management. Drs. Zipes, Jalife, and a host of other world leaders in cardiac electrophysiology use a comprehensive, multidisciplinary approach to guide you through all of the most recent cardiac drugs, techniques, and technologies. Get well-rounded, expert views of every cardiac electrophysiology issue that affects your patient management from preeminent authorities in cardiology, physiology, pharmacology, pediatrics, biophysics, pathology, cardiothoracic surgery, and biomedical engineering from around the world |
| Bibliography |
Includes bibliographical references and index |
| Subject |
Arrhythmia.
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Heart -- Electric properties.
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Arrhythmias, Cardiac
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Electrophysiologic Techniques, Cardiac
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Heart -- physiology
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Arrhythmia
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Heart -- Electric properties
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| Form |
Electronic book
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| Author |
Zipes, Douglas P., editor.
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Jalife, José, editor.
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| ISBN |
9781455770106 |
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1455770108 |
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