| Description |
1 online resource (viii, 447 pages) : illustrations (some color) |
| Series |
Handbook of Experimental Pharmacology, 0171-2004 ; volume 219 |
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Handbook of experimental pharmacology ; v. 219. 0171-2004
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| Contents |
880-01 Therapeutic potential of small molecules and engineered proteins.-arrestin interactions with g protein-coupled receptors -- arrestin-biased gpcr¡agonists -- arrestin-1 expression levels, rod function and health -- protective functions of arrestin-1 in photoreceptors -- arrestin-4 and cone function -- enhanced phosphorylation-independent arrestins and gene therapy -- targeting particular receptors with redesigned non-visual arrestins.-¡arrestins binding to clathrin, ap2 and role in gpcr trafficking -- arrestins in ubiquitination and deubiquitination -- arrestin self-association -- arrestin-dependent activation of erk and src -- arrestin-dependent activation of jnk family kinases -- arrestin-mediated p38 activation.-¡arrestin-dependent pde localization -- arrestins in cell migration -- arrestins in host-pathogen interactions -- arrestin regulation of small gtpases -- gpcrs and arrestins in airways: implications for asthma -- arrestins as regulatory signaling hubs in cancer pathways -- arrestins in pain and anesthesia |
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880-01/(S Therapeutic Potential of Small Molecules and Engineered Proteins / Eugenia V. Gurevich and Vsevolod V. Gurevich -- Part I. Arrestins and Regulation of G Protein-Coupled Receptors -- Arrestin Interactions with G Protein-Coupled Receptors / Martin J. Lohse and Carsten Hoffmann -- Quantifying Biased β-Arrestin Signaling / Terry Kenakin -- The Physiological Roles of Arrestin-1 in Rod Photoreceptor Cells / Jeannie Chen -- Not Just Signal Shutoff: The Protective Role of Arrestin-1 in Rod Cells / Martha E. Sommer, Klaus Peter Hofmann and Martin Heck -- Cone Arrestin: Deciphering the Structure and Functions of Arrestin 4 in Vision / Cheryl Mae Craft and Janise D. Deming -- Enhanced Phosphorylation-Independent Arrestins and Gene Therapy / Vsevolod V. Gurevich, Xiufeng Song, Sergey A. Vishnivetskiy and Eugenia V. Gurevich -- Targeting Individual GPCRs with Redesigned Nonvisual Arrestins / Luis E. Gimenez, Sergey A. Vishnivetskiy and Vsevolod V. Gurevich -- Part II. Arrestin Interactions with Non-receptor Partners and Roles in Cell Signaling -- β-Arrestins and G Protein-Coupled Receptor Trafficking / Xufan Tian, Dong Soo Kang and Jeffrey L. Benovic -- Arrestin Interaction with E3 Ubiquitin Ligases and Deubiquitinases: Functional and Therapeutic Implications / Sudha K. Shenoy -- Self-Association of Arrestin Family Members / Qiuyan Chen, Ya Zhuo, Miyeon Kim, Susan M. Hanson, Derek J. Francis [and 5 others] -- Arrestin-Dependent Activation of ERK and Src Family Kinases / Erik G. Strungs and Louis M. Luttrell -- Arrestin-Dependent Activation of JNK Family Kinases / Xuanzhi Zhan, Seunghyi Kook, Eugenia V. Gurevich and Vsevolod V. Gurevich -- Arrestin-Mediated Activation of p38 MAPK: Molecular Mechanisms and Behavioral Consequences / Charles Chavkin, Selena S. Schattauer and Jamie R. Levin -- Arrestin-Dependent Localization of Phosphodiesterases / Miranda J. Willis and George S. Baillie -- Arrestins in Apoptosis / Seunghyi Kook, Vsevolod V. Gurevich and Eugenia V. Gurevich -- Molecular Mechanisms Underlying Beta-Arrestin-Dependent Chemotaxis and Actin-Cytoskeletal Reorganization / Kathryn W. McGovern and Kathryn A. DeFea -- Arrestins in Host-Pathogen Interactions / Stefano Marullo and Mathieu Coureuil -- Arrestin Regulation of Small GTPases / Ryan T. Cameron and George S. Baillie -- GPCRs and Arrestins in Airways: Implications for Asthma / Raymond B. Penn, Richard A. Bond and Julia K.L. Walker -- Arrestins as Regulatory Hubs in Cancer Signalling Pathways / Hervé Enslen, Evelyne Lima-Fernandes and Mark G.H. Scott -- β-Arrestins: Regulatory Role and Therapeutic Potential in Opioid and Cannabinoid Receptor-Mediated Analgesia / Kirsten M. Raehal and Laura M. Bohn |
| Summary |
This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting arrestin interactions with individual partners |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed December 3, 2013) |
| Subject |
Arrestins.
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Arrestins
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Arrestin
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SCIENCE -- Life Sciences -- Biochemistry.
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Arrestins
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| Form |
Electronic book
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| Author |
Gurevich, Vsevolod V., editor
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| ISBN |
9783642411991 |
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3642411991 |
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