| Description |
1 online resource (584 pages) |
| Contents |
Cover; Half Title; Title Page; Table of Contents; Preface; Chapter 1 Reductones as a variety of antioxidants of the biotic type; 1.1. Introduction; 1.2. Natural reduetones; 1.2.1. Ascorbic acid (AA); 1.2.1.1. Redox properties; 1.2.1.2. Antioxidant properties; 1.2.1.3. Catalytic control of AA activity; 1.2.1.4. Synergism; 1.2.1.5. AA and metals; 1.2.1.6. Prooxtdant activity; 1.2.1. 7. The ratio of antioxidant and prooxidant activities; 1.2.1.8. Intermediate conclusions; 1.2.2. Coumarin reductones of the aliphatic type; 1.2.3. Polyphenols of plant and animal origin; 1.2.3.1. Coumarins |
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1.2.3.2. Noneyclic analogues of coumarin1.2.3.3. Flavonoids; 1.2.3.4. Hydroquinones and qutnones, chromanes and chromenes; 1.2.3.5. Catecholamines; 1.2.4. Other heterocyclic compounds; 1.2.4.1. Pyrrolohydroquinoneine quinone and quinoproteins; 1.2.4.2. Hydroxypyridones and hydroxypyrones; 1.2.4.3. Substitutedpyrimidines; 1.3. Conclusion; Chapter 2 Antitumour potential of superoxide dismutase model; 2.1. Introduction; 2.1.1. The notion of superoxide dismutase models; 2.1.2. Superoxide dismutases and cancer; 2.1.3. SOD models and cancer; 2.1.4. Copper metabolism and oncological diseases |
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2.1.5. Antitumor effects of inorganic copper salts2.2. The search for antitumor agents among complex copper compounds; 2.2.1. Salicylate SOD models; 2.2.2. Other carboxyblte SOD models; 2.2.3. Amino acid and peptide SOD models; 2.2.4. Other types of SOD models; 2.2.5. Stable SOD models; 2.2.6. The search for effective chelators; 2.2.7. Concept of iron chelators; 2.2.8. Principles of SOD model design; 2.3. Molecular mechanisms of the SOD model antitumor effects; 2.3.1. SOD models as anticarcinogens; 2.3.2. SOD models as antitumor agents |
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2.3.2.1. Resemblance and differences between SOD models and enzymes2.3.2.2. Probable functions of SOD models in biological systems; 2.3.3. Prooxidant activity of SOD models; 2.3.3.1. Analogy with antitumor antibiotics; 2.3.3.2. Mechanisms of DNA damage; 2.3.3.3. Mechanisms of protein damage; 2.3.4. Mechanisms of physiological compatibility of SOD models; 2.3.4.1. Selection of ligands for the SOD model design; 2.3.4.2. Effects on the cell redox potential; 2.3.4.3. Interaction with the immune system; 2.3.4.4. Gene expression; 2.3.4.5. Overcoming drug resistance |
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2.3.5 Is an Universal Antioxidant Possible?Chapter 3 How to transform available knowledge into specific elaborations; 3.1 Raw materlal sources and technological scheme; 3.2 Estimation of the possibilities of the technological scheme suggested by the assortment of products; 3.3 Conclusion; Subject Index; List of Abbreviations |
| Notes |
Print version record |
| Subject |
Antineoplastic agents.
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Superoxide dismutase.
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Reductones.
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Antioxidants -- Therapeutic use
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Superoxide Dismutase
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Antineoplastic agents.
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Antioxidants -- Therapeutic use.
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Reductones.
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Superoxide dismutase.
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| Form |
Electronic book
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| Author |
Zaikov, Gennadii Efremovich
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| ISBN |
9781351463522 |
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1351463527 |
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