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Title Relevance of tumor models for anticancer drug development / volume editors, H.-H. Fiebig, A.M. Burger
Published Basel ; New York : Karger, 1999
Online access available from:
Karger eBooks Collection    View Resource Record  


Description 1 online resource (viii, 462 pages) : illustrations
Series Beiträge zur Onkologie ; vol. 54
Beiträge zur Onkologie ; vol. 54
Summary In recent years, large-scale 'disease-oriented' and 'target-oriented' screening procedures have transformed anticancer drug discovery. As a result several novel therapeutic agents and strategies, aimed to combat cancer via a molecular approach, are being evaluated for their possible clinical benefit. The main topics of this volume address the challenges for current drug development and the available preclinical in vivo and in vitro model systems. Special new techniques to mimic the clinical situation in the mouse, models to evaluate metastasis and angiogenesis inhibitors, new molecular targets for anticancer drug development and their preclinically/clinically examined inhibitors or modulators are described. Furthermore, the recent testing procedures for the discovery of novel therapeutic agents employed at the US National Cancer Institute (e.g. Hollow Fiber Assay) and at the European Organization for Research and Treatment of Cancer (EORTC) - Screening and Pharmacology Group (SPG) - are reviewed.This volume will provide a comprehensive overview of the up-to-date drug discovery and development strategies for medical oncologists, experimental cancer researchers, cancer research institutions, and the pharmaceutical industry
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Animals.
Drug Evaluation, Preclinical.
Antineoplastic Agents -- therapeutic use.
Disease Models, Animal.
Antineoplastic agents x̲ Testing -- Congresses
Cancer x̲ Chemotherapy x̲ Evaluation -- Congresses
Tumors -- Animal models.
Genre/Form Congress.
Internet Resources
Conference papers and proceedings.
Conference papers and proceedings.
Form Electronic book
Author Burger, A. M.
Fiebig, H. H.
ISBN 3318034371
(hardcover ; alk. paper)
(hardcover ; alk. paper)