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Title Pathobiology of cancer regimen-related toxicities / Stephen Sonis, Dorothy Keefe, editors
Published New York ; London : Springer, 2013


Description 1 online resource
Contents General concepts affecting regimen-related toxicities -- Epidemiology and Outcomes of Regimen-Related Toxicities / Linda S. Elting, Yu-Chia Chang, Pratibha Parelkar -- The Biological Basis for Differences in Normal Tissue Response to Radiation Therapy and Strategies to Establish Predictive Assays for Individual Complication Risk / Christian Nicolaj Andreassen -- The Ionizing Radiation-Induced Bystander Effect: Evidence, Mechanism, and Significance / Edouard I. Azzam, Sonia M. de Toledo, Andrew L. Harris, Vladimir Ivanov, Hongning Zhou -- The Role of Genes on the Metabolism of Chemotherapeutic Agents and Their Impact on Toxicity / Young S. Yi, Gil Alterovitz -- Animal Models of Regimen-Related Toxicities / Gregory Lyng, Richard Logan, Maria Mancini -- The Pathobiology of Specific Toxicities -- Nausea and Vomiting / Pernille H. Hansen, Jesper Palshof, Jørn Herrstedt -- Mucositis / Noor Al-Dasooqi, Dorothy M. Keefe, Dorothy M. Keefe, Stephen T. Sonis -- Dermatitis and Alopecia / Yevgeniy Balagula, Mario E. Lacouture -- Fibrosis / Lynne A. Murray, Matthew A. Sleeman -- Myelosuppression / David C. Dale -- Neuropathy / Elizabeth K. Joseph M. Pharm, -- Mechanisms of Cancer Related Fatigue / Jonathan A. Zombeck -- Xerostomia / Ana P. Cotrim, Changyu Zheng, Bruce J. Baum -- Osteonecrosis / Caterina Musolino, Alessandro Allegra -- Conclusions and therapeutic opportunities -- Conclusion / Stephen T. Sonis
Summary Toxicities have been consistent undesirable companions of every form of radiation and drug cancer treatment regimens. In addition to the potential for toxicities to devastate patients' quality of life, they generate huge incremental financial costs, and sap patients' ability to tolerate definitive cancer therapy. And every new drug or biological has come with new side effects. Historically, regimen-related toxicities were viewed as the inevitable cost of treating cancer. But this may be about to change. Discoveries in the past dozen years have painted a new picture of the pathobiology of almost all regimen-related toxicities. The mechanistic complexities that underlie radiation- and chemotherapy-induced tissue injury or systemic symptoms have been pieced together in an incremental sequence which now provides multiple targets for effective toxicity interventions. This book brings together, for the first time in a single volume, the most current information regarding both general principles guiding current thinking about the pathogenesis of regimen-related toxicities and the specific biological underpinnings of the most common side effects of cancer therapy. The contents provide information that is essential to clinicians and basic and translational scientists interested in cancer therapy and its toxicities
Notes Print version record
Subject Cancer -- Treatment -- Complications.
Antineoplastic agents -- Toxicology
Antineoplastic Agents -- adverse effects
Antineoplastic Agents -- toxicity
Antineoplastic Agents -- therapeutic use
HEALTH & FITNESS -- Diseases -- Cancer.
MEDICAL -- Oncology.
Antineoplastic agents -- Toxicology.
Cancer -- Treatment -- Complications.
Form Electronic book
Author Sonis, Stephen T.
Keefe, Dorothy
ISBN 9781461454380