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Book Cover
E-book

Title Drugs for HER2-positive breast cancer / volume editor, Christoph C. Zielinski [and others]
Published Basel : Birkhäuser ; London : Springer [distributor], 2010

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Description 1 online resource
Series Milestones in drug therapy
Milestones in drug therapy.
Contents Drugs for HER-2-positive Breast Cancer: A Major Approval for Translational Cancer Research (Maria Sibilia, Christoph C. Zielinski, Rupert Bartsch, Thomas Grunt) -- The EGFR/ErbB family in breast cancer: from signaling to therapy (Wolfgang J. Köstler and Yosef Yarden) -- Trastuzumab as Adjuvant treatment for early stage HER-2 positive breast cancer (Rupert Bartsch and Guenther G. Steger) -- Trastuzumab Resistance in breast cancer (Floriana Morgillo, Michele Orditura, Teresa Troiani, Erika Martinelli, Ferdinando De Vita, Fortunato Ciardiello) -- Treatment with Trastuzumab beyond Progression (Gunter von Minckwitz and Cristina Pirvulescu) -- Pertuzumab -- a HER-2 dimerisation inhibitor -- for the treatment of breast and other cancers (Giulia Bianchi and Luca Gianni) -- Beyond trastuzumab: Second generation targeted therapies for HER2 -- positive breast cancer (Flavio F. Solca, Guenther R. Adolf, Hilary Jones, Martina M. Uttenreuther-Fischer)
Summary Growth factor receptors have long been known to drive malignant transformation and cancer progression. The epidermal growth factor receptor (EGFR, ErbB, HER) system is likely the best described membrane receptor tyrosine kinase family in malignant tumors. With implementation of the growth-inhibitory anti-HER-2 antibody trastuzumab (Herceptin) for the treatment of HER-2-positive advanced metastatic breast cancer, a new era has dawned in the therapy of this malignant disease. Unfortunately, trastuzumab-sensitive cancers invariably develop resistance to the antibody after some time. Recent clinic
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Trastuzumab.
BRCA genes.
Cancer -- Gene therapy.
Breast -- Cancer -- Chemotherapy
HER-2 gene.
Antibodies, Monoclonal -- pharmacology
Antibodies, Monoclonal -- therapeutic use
Antineoplastic Agents -- therapeutic use
Breast Neoplasms -- drug therapy
Genes, erbB-2
Molecular Targeted Therapy -- methods
MEDICAL -- Pharmacology.
HER-2 gene
BRCA genes
Breast -- Cancer -- Chemotherapy
Cancer -- Gene therapy
Trastuzumab
Form Electronic book
Author Zielinski, Christoph C., 1952-
ISBN 9783034600941
3034600941