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Author Kiang, Tony K. L., author

Title Clinical pharmacokinetic and pharmacodynamic drug interactions associated with antimalarials / Tony K.L. Kiang, Kyle John Wilby, Mary H.H. Ensom
Published [Cham] : Adis, [2015]


Description 1 online resource
Contents Introduction -- Pharmacology of Recommended Antimalarial Agents -- Drug Interaction Potential of Antimalarial Drugs Based on Known Metabolic Properties of Antimalarials -- Pharmacokinetic Drug Interactions Affecting Antimalarials -- Effects of Antimalarials on the Pharmacokinetics of Co-Administered Drugs -- Effects of Antimalarials on the Pharmacokinetics of Co-Administered Antimalarials -- Pharmacodynamic Interactions: Clinical Evidence for Combination Therapy, In Vitro Interactions, and In Vivo Interactions -- Limitations, Future Directions, and Conclusions
Summary This comprehensive review provides a systematic, unbiased analysis, critique and summary of the available literature and generates novel clinical decision-making algorithms which can aid clinicians and scientists in practice management and research development. Potential mechanisms for the identified drug interactions are deduced from available preclinical and in vitro data which are interpreted in the context of the in vivo findings. Current limitations and gaps in the literature are summarized, and potential future research directions / experimentations are also suggested. In addition to the main objective to review the available clinical pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antimalarial drugs on the market today (i.e. chloroquine, amodiaquine, sulfadoxine, pyrimethamine, mefloquine, artemisinin, artemether, artesunate, dihydroartemisinin, artemotil, lumefantrine, primaquine, atovaquone, proguanil, piperaquine and quinine), this book also provides succinct chapter summaries on the epidemiology of malaria infection, diagnosis and therapeutics, in vivo pharmacology and chemistry, preclinical pharmacology, in vitro pharmacodynamics, in vitro reaction phenotyping, and in vitro drug-drug interaction data associated with the identified antimalarial drugs
Analysis tropische geneeskunde
tropical medicine
public health
disease prevention
Medicine (General)
Geneeskunde (algemeen)
Bibliography Includes bibliographical references
Notes Online resource; title from pdf information screen (EBSCO, viewed November 14, 2014)
Subject Antimalarials -- Pharmacokinetics
Antimalarials -- Receptors -- Effect of drugs on
Antimalarials -- pharmacokinetics
Public health & preventive medicine.
Tropical medicine.
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Form Electronic book
Author Wilby, Kyle John, author
Ensom, Mary H. H., author
ISBN 9783319105277