| Description |
1 online resource (xiii, 199 pages) : illustrations (chiefly color) |
| Contents |
Intro -- Preface -- Contents -- About the Author -- 1: Introduction: An Overview of Malaria and Plasmodium -- 1.1 Introduction -- 1.1.1 The Struggle of Human Beings Against Malaria, Both in the Past and in the Present -- 1.2 Life Cycle of Plasmodium -- 1.3 Recurrence of Malaria and the Hypnozoite -- 1.4 Gametocytes -- 1.5 Asymptomatic Carriers -- 1.6 Apicoplast and Plant-Like Metabolism -- 1.7 Antimalarial Drugs and Resistance -- 1.8 Host Specificity -- 1.9 Conclusions -- References -- 2: Pathogenesis of Plasmodium falciparum -- 2.1 Introduction |
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2.2 The Symptoms of P. falciparum Infection -- 2.3 Results of Histopathology: Parasite Sequestration in P. falciparum Malaria -- 2.4 Sequestration Plays a Role in the Development of Serious Malarial Disease -- 2.5 Metabolic Abnormalities, Responses, and Toxic Mediators -- 2.6 Infection by Plasmodium falciparum and Red Blood Cell Adherence -- 2.7 Adhesion Receptors in Parasites -- 2.8 CD36: A Membrane Glycoprotein -- 2.9 ICAM-1: Glycoprotein and Adhesion Receptor -- 2.10 CSA (Central Sleep Apnea) -- 2.11 HA: Hemagglutinin -- 2.12 Receptors for Rosettes -- 2.13 Additional Receptors |
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2.14 Adhesion of Molecules to Parasites in Plasmodium falciparum -- 2.15 Different Ligands -- 2.16 Antigenic Shifts in Malaria-Infected Red Blood Cells -- 2.17 Immunity to a Certain Variant -- 2.18 Pregnancy-Related Malaria -- 2.19 Conclusion -- References -- 3: Antimalarial Drugs and Drug Resistance -- 3.1 Introduction -- 3.2 Malaria Pathogenesis: Overview -- 3.3 Antimalarial Drugs: Summary -- 3.4 Mechanism of Antimalarial Drug Resistance -- 3.4.1 Chloroquine Resistance in Plasmodium falciparum: Overview -- 3.4.2 Other Drug Resistance Genetic Markers |
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3.4.3 Artemisinin Resistance in Plasmodium falciparum -- 3.5 Latest Targets for Antimalarials -- 3.5.1 Use of Chemo-Protectants -- 3.5.2 Gametocytes as Drug Targets -- 3.5.3 Plant-Based Antimalarials -- 3.5.4 Injectable Antimalarials -- 3.5.5 Malaria Vaccines -- 3.6 Changes in Antimalarial Target Candidate and Target Product Profiles Over the Past Few Years -- 3.7 WHO Malaria Report 2021 -- 3.8 Concluding Remarks -- References -- 4: Metabolic Pathways of Enzymes: Therapeutic Targets and Prospects for Innovative Antimalarial Drugs -- 4.1 Introduction -- 4.2 Hypothetical Model |
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4.3 Antimalarial Resistance -- 4.4 Antimalarial Target -- 4.5 Mitochondrion Target and Plasmodium -- 4.6 Apicoplast Target -- 4.7 Cytoplasmic Target -- 4.8 Enzymes Involved in Folate Pathway -- 4.9 Enzymes Involved in Glycotic Pathway -- 4.10 Computational Approach -- 4.11 Natural Products -- 4.12 High Throughput Screening -- 4.13 Conclusion -- References -- 5: Targeting Apicoplasts in Plasmodium falciparum, Origin and Pathways -- 5.1 Introduction -- 5.2 Hypothetical Model -- 5.3 Origin and Structure of Apicoplast -- 5.4 Drug Target and Role of Apicoplast |
| Summary |
This book offers a comprehensive exploration of malaria, a life-threatening disease affecting millions globally, with a focus on the parasitic organisms of the genus Plasmodium that cause it. It discusses the challenges posed by the disease, especially in economically developing regions, and delves into the biology and pathophysiology of the Plasmodium species, including their genetic flexibility and resistance to treatments. Special attention is given to P. falciparum, the most dangerous of these parasites, detailing its complex life cycle, interaction with human hosts, and the severe clinical manifestations it can induce. The book further explores the global health concern of antimalarial drug resistance, highlighting the WHO's efforts in combating the disease and the necessity for novel treatments. Innovative research directions, such as targeting the unique organelles of Plasmodium like the apicoplast and employing proteasome inhibitors, are thoroughly examined as potential strategies in the development of new antimalarial drugs. Additionally, it addresses the critical role of the hemoglobin digestion process in the parasite's lifecycle, presenting it as a promising target for therapeutic intervention. This work is an essential resource for researchers, clinicians, and policymakers involved in malaria control and drug development, providing insights into the current challenges and future directions in the fight against this endemic disease |
| Bibliography |
Includes bibliographical references |
| Subject |
Malaria -- Treatment
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Antimalarials.
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Drug resistance in microorganisms.
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Plasmodium falciparum.
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| Form |
Electronic book
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| ISBN |
9789811944840 |
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9811944849 |
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