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Author Kropshofer, Harald.

Title Antigen presenting cells : from mechanisms to drug development / edited by Harald Kropshofer and Anne B. Vogt
Published Weinheim : Wiley-VCH, [2005]
Online access available from:
Wiley Online Books    View Resource Record  


Description 1 online resource (xl, 611 pages, color plates)
Contents pt. I. Antigen presentation in the immune system, 1. Some old some new findings on atigen processing and presentation / Emil R. Unanue -- pt. II. Molecular mechanisms of antigen processing, 2. Antigen entry routes : where foreign invaders meet antigen presenting cells / Percy A. Knolle ; 3. Antigen processing in the context of MHC class I molecules / Frank Momburg ; 4. Antigen processing for MHC class II / Anne B. Vogt ... et al. ; 5. Antigen processing and presentation by CD1 family proteins / Steven A. Porcelli and D. Branch Moody -- pt. III. Antigen presenting cells' ligands recognized by T- and toll-like receptors, 6. Naturally processed self-peptides of MHC molecules / Harald Kropshofer and Sebastian Spindeldreher ; 7. Target cell contributions to cytotoxic T cell sensitivity / Tatiana Lebdeva ... et al. ; 8. Stimulation of antigen presenting cells : from classical adjuvants to toll-like receptor (TLR) ligands / Martin F. Bachmann and Annette Oxenius -- pt. IV. The repertoire of antigen presenting cells, 9. Evolution and diversity of macrophages / Nicholas S. Stoy ; 10. Macrophages : balancing tolerance and immunity / Nicholas S. Stoy ; 11. Polymorphonuclear neutrophils an antigen-presenting cells / Amit R. Ashtekar and Bhaskar Saha ; 12. Microglia : the professional antigen-presenting cells of the CNS? / Monica J. Carson ; 13. Contribution of B cells to autoimmune pathogenesis / Thomas Dörner and peter E. Lipsky ; 14. Dendritic cells (DCs) in immunity and maintenance of tolerance / Magali de Heusch ... et al. ; 15. Tymic dendritic cells / Kenneth Shortman and Li Wu -- pt. V. Antigen presenting cell-based drug development, 16. Antigen presenting cells and drug targets
Summary This novel, multidisciplinary handbook highlights recent evidence that antigen presenting cells (APCs) are not only key players in the initiation or prevention of an antigen-specific T lymphocyte-mediated adaptive immune response, but also critical regulators and integrators in the interplay between our innate and adaptive immune system. Structured in a clear way to allow access to a very broad readership, the book is written from the viewpoint of a biochemist, immunologist, and scientist with experience in drug development. It covers all cell types involved in antigen presentation, providing
Notes Includes glossary and index
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Antigen presenting cells.
Antigen-Presenting Cells -- immunology.
Form Electronic book
Author Vogt, Anne B.
John Wiley & Sons.
ISBN 1280854073
3527311084 (print edition)
352760698X (electronic bk.)
3527607021 (electronic bk.)
9783527311088 (print edition)
9783527606986 (electronic bk.)
9783527607020 (electronic bk.)