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Title CD14 in the inflammatory response / volume editor, Robert S. Jack
Published Basel ; New York : Karger, ©2000


Description 1 online resource (viii, 182 pages) : illustrations (some color)
Series Chemical immunology ; vol. 74
Chemical immunology ; v. 74
Contents Introduction : hunting devils -- Chemical structure, molecular conformation and bioactivity of endotoxins -- Structure/function relationships of CD14 -- Lipopolysaccharide-binding protein -- Role of CD14 in cellular recognition of bacterial lipopolysaccharides -- Interactions of CD14 with components of gram-positive bacteria -- Soluble CD14-mediated cellular responses to lipopolysaccharide -- Non-inflammatory/anti-inflammatory CD14 responses : CD14 in apoptosis -- TNF in the inflammatory response -- Clinical aspects : from systemic inflammation to "immunoparalysis."
Summary In a world full of pathogens the ability to detect an incipient infection and to respond rapidly and appropriately to it is a decisive part of our survival strategy. The innate immune system provides the first response to an infection by initiating an inflammatory response and the monocyte surface molecule CD14 is a key element in this response system. The initial chapters in this volume describe the structure and ligand interactions of this important receptor molecule which is involved both in inflammation and in some aspects of apoptosis. The very recent results which illuminate the probable signal transduction pathways are also described. Overactivation of the inflammatory response can lead to systemic inflammation and septic shock. Attempts to intervene clinically in this system have been disappointing, and the reasons for these failures are discussed in the context of the expression of TNF which is upregulated by CD14. A discussion of new data on the clinical course of shock and the currently emerging therapeutic strategies rounds off the book. The information compiled in this well-edited volume will be of use to everyone working on problems of inflammation - a topic where fundamental research and clinical medicine meet. Clinicians will find the current state of scientific knowledge on the inflammatory response as induced via CD14 presented in a readable form, while the clinical aspects discussed will be of particular interest to scientists and students who lack a medical background
Bibliography Includes bibliographical references and indexes
Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. MiAaHDL
Print version record
digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL
Subject CD antigens -- Immunology
Endotoxins -- Physiological effect
Systemic Inflammatory Response Syndrome
Lipopolysaccharide Receptors
Endotoxins -- Physiological effect
Antigen CD14
Entzündung -- Antigen CD14 -- Aufsatzsammlung.
Antigen CD14 -- Entzündung -- Aufsatzsammlung.
Genre/Form Aufsatzsammlung.
Form Electronic book
Author Jack, Robert S
ISBN 9783318004632