| Description |
1 online resource (xl, 611 pages, color plates) |
| Contents |
pt. I. Antigen presentation in the immune system, 1. Some old some new findings on atigen processing and presentation / Emil R. Unanue -- pt. II. Molecular mechanisms of antigen processing, 2. Antigen entry routes : where foreign invaders meet antigen presenting cells / Percy A. Knolle ; 3. Antigen processing in the context of MHC class I molecules / Frank Momburg ; 4. Antigen processing for MHC class II / Anne B. Vogt ... et al. ; 5. Antigen processing and presentation by CD1 family proteins / Steven A. Porcelli and D. Branch Moody -- pt. III. Antigen presenting cells' ligands recognized by T- and toll-like receptors, 6. Naturally processed self-peptides of MHC molecules / Harald Kropshofer and Sebastian Spindeldreher ; 7. Target cell contributions to cytotoxic T cell sensitivity / Tatiana Lebdeva ... et al. ; 8. Stimulation of antigen presenting cells : from classical adjuvants to toll-like receptor (TLR) ligands / Martin F. Bachmann and Annette Oxenius -- pt. IV. The repertoire of antigen presenting cells, 9. Evolution and diversity of macrophages / Nicholas S. Stoy ; 10. Macrophages : balancing tolerance and immunity / Nicholas S. Stoy ; 11. Polymorphonuclear neutrophils an antigen-presenting cells / Amit R. Ashtekar and Bhaskar Saha ; 12. Microglia : the professional antigen-presenting cells of the CNS? / Monica J. Carson ; 13. Contribution of B cells to autoimmune pathogenesis / Thomas Dörner and peter E. Lipsky ; 14. Dendritic cells (DCs) in immunity and maintenance of tolerance / Magali de Heusch ... et al. ; 15. Tymic dendritic cells / Kenneth Shortman and Li Wu -- pt. V. Antigen presenting cell-based drug development, 16. Antigen presenting cells and drug targets |
| Summary |
This novel, multidisciplinary handbook highlights recent evidence that antigen presenting cells (APCs) are not only key players in the initiation or prevention of an antigen-specific T lymphocyte-mediated adaptive immune response, but also critical regulators and integrators in the interplay between our innate and adaptive immune system. Structured in a clear way to allow access to a very broad readership, the book is written from the viewpoint of a biochemist, immunologist, and scientist with experience in drug development. It covers all cell types involved in antigen presentation, providing |
| Notes |
Includes glossary and index |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Antigen presenting cells.
|
|
Antigen-Presenting Cells -- immunology.
|
| Form |
Electronic book
|
| Author |
Vogt, Anne B.
|
|
John Wiley & Sons.
|
| ISBN |
1280854073 |
|
3527311084 (print edition) |
|
352760698X (electronic bk.) |
|
3527607021 (electronic bk.) |
|
9781280854071 |
|
9783527311088 (print edition) |
|
9783527606986 (electronic bk.) |
|
9783527607020 (electronic bk.) |
|
