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Title Ricin and shiga toxins : pathogenesis, immunity, vaccines and therapeutics / Nicholas Mantis, editor
Published Berlin ; New York : Springer, ©2012


Description 1 online resource (xi, 276 pages)
Series Current topics in microbiology and immunology, 0070-217X ; v. 357
Current topics in microbiology and immunology ; v. 357.
Contents Interaction of Ricin and Shiga Toxins with Ribosomes -- How Ricin and Shiga Toxin Reach the Cytosol of Target Cells: Retrotranslocation from the Endoplasmic Reticulum -- Ricin and Shiga Toxins: Effects on Host Cell Signal Transduction -- Pathogenesis of Shiga-Toxin Producing Escherichia coli -- Shiga Toxin Pathogenesis: Kidney Complications and Renal Failure -- The Induction of Apoptosis by Shiga Toxins and Ricin -- Small-Molecule Inhibitors of Ricin and Shiga Toxins -- Immunity to Ricin: Fundamental Insights into Toxin-Antibody Interactions -- Animal Models of Ricin Toxicosis -- Ricin Vaccine Development
Summary Annotation In May of 2011, Western Europe experienced a severe outbreak of Shiga toxin (Stx)-producing E. coli (STEC) that culminated in more than 3200 cases and 39 deaths. While Stx is not the only virulence factor associated with STEC, it is certainly the primary determinant associated with the onset of hemolytic uremic syndrome (HUS). At the present time, there are no clinically approved measures to neutralize Stx in individuals suffering from STEC infection. Nor are there any preventatives or therapeutics for ricin toxin. Although incidents of ricin exposure are largely unheard of, federal agencies and public health officials consider it a significant threat. It is well documented that domestic and international terrorist groups have stockpiled, and in some cases weaponized ricin with the intent of releasing it into the public sphere and causing panic, illness and/or death on a local, regional, or possibly national scale. The chapters, written by leading experts in the field, are organized so as to cover all aspects of ricin and Stx, including pathogenesis, immunity, vaccines and therapeutics. This outstanding collection of reviews will serve as an important and readily accessible resource for the research community in the coming years
Analysis Medicine
Bibliography Includes bibliographical references and index
Subject Ricin.
Chemical agents (Munitions) -- Toxicology
Antigens and Antibodies
Shiga Toxins
Toxins, Biological
MEDICAL -- Toxicology.
Chemical agents (Munitions) -- Toxicology
Form Electronic book
Author Mantis, Nicholas J.
ISBN 9783642274701