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Book Cover
Author Rogers, P. David

Title Antifungal Agents : Methods and Protocols
Published Totowa : Humana Press, 2006


Description 1 online resource (222 pages)
Contents Antifungal Agents: Methods and Protocols; Preface; Contents; Contributors; PART I. INTRODUCTION; 1 Susceptibility Testing Methods of Antifungal Agents; PART II. ANTIFUNGAL RESISTANCE; 2 Deoxyribonucleic Acid Fingerprinting Methods for Candida Species ; 3 CARE-2 Fingerprinting of Candida albicans Isolates ; 4 Targeted Gene Deletion in Candida Strains by MPAR Flipping; 5 Application of Deoxyribonucleic Acid Microarray Analysis to the Study of Azole Antifungal Resistance in Candida albicans; 6 Application of Proteomic Analysis to the Study of Azole Antifungal Resistance in Candida albicans
7 Techniques for Antifungal Susceptibility Testing of Candida albicans BiofilmsPART III. ANTIFUNGAL DEVELOPMENT AND EVALUATION; 8 Natural Products and Antifungal Drug Discovery; 9 Use of an Animal Model of Disseminated Candidiasis in the Evaluation of Antifungal Therapy; 10 Murine Model of Invasive Aspergillosis; 11 Antifungal Combinations; 12 Postantifungal Effect Methods; PART IV. HOST RESPONSES AND IMMUNOTHERAPY; 13 Evaluation of Immunotherapy in Invasive Candidiasis; 14 Interaction of Histoplasma capsulatum With Human Macrophages, Dendritic Cells, and Neutrophils
Summary With the growing frequency of fungal infections even as resistance to existing antifungal agents increases, methods for finding novel drug targets and evaluating antifungal resistance have become more important than ever. In Antifungal Agents: Methods and Protocols, expert scientists describe in detail the state-of-the-art molecular methods they have optimized for studying antifungal resistance, for discovering and evaluating both new and existing antifungal drugs, and for understanding the host response and immunotherapy of such agents. Many of the protocols were developed in the laboratory and, when a method is limited to specific organisms, include alternative techniques to expand their application. The protocols follow the successful Methods in Molecular Medicineā„¢ series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and highly practical, Antifungal Agents: Methods and Protocols offers clinician-scientists, microbiologists, and molecular biologists the productive tools they need today in order to understand and successfully develop new therapeutic agents for yeast, mold, and fungal infections
Notes 15 Immunology of Infection Caused by Cryptococcus neoformansIndex
Print version record
Subject Antifungal agents -- Research -- Methodology
Medical mycology -- Immunotherapy
Drug resistance in microorganisms.
Anti-infective agents.
Life sciences.
Fungi imperfecti.
Drug resistance.
Yeast fungi.
Physical sciences.
Candida albicans.
Drug Resistance, Microbial
Anti-Infective Agents
Investigative Techniques
Therapeutic Uses
Biological Science Disciplines
Analytical, Diagnostic and Therapeutic Techniques and Equipment
Mitosporic Fungi
Bacterial Infections and Mycoses
Drug Resistance
Microbiological Phenomena
Phenomena and Processes
Pharmacological Phenomena
Natural Science Disciplines
Pharmacologic Actions
Physiological Phenomena
Disciplines and Occupations
Chemical Actions and Uses
Chemicals and Drugs
Drug Resistance, Fungal
Candida albicans
Antifungal Agents
Models, Animal
biological sciences.
physical sciences.
Yeast fungi
Physical sciences
Life sciences
Fungi imperfecti
Drug resistance in microorganisms
Drug resistance
Candida albicans
Anti-infective agents
Form Electronic book
Author Ernst, Erika J
ISBN 9781592599431