Title Antifungal Agents : Methods and Protocols

Published Totowa : Humana Press, 2006

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Description 1 online resource (222 pages) Contents Antifungal Agents: Methods and Protocols; Preface; Contents; Contributors; PART I. INTRODUCTION; 1 Susceptibility Testing Methods of Antifungal Agents; PART II. ANTIFUNGAL RESISTANCE; 2 Deoxyribonucleic Acid Fingerprinting Methods for Candida Species ; 3 CARE-2 Fingerprinting of Candida albicans Isolates ; 4 Targeted Gene Deletion in Candida Strains by MPAR Flipping; 5 Application of Deoxyribonucleic Acid Microarray Analysis to the Study of Azole Antifungal Resistance in Candida albicans; 6 Application of Proteomic Analysis to the Study of Azole Antifungal Resistance in Candida albicans 7 Techniques for Antifungal Susceptibility Testing of Candida albicans BiofilmsPART III. ANTIFUNGAL DEVELOPMENT AND EVALUATION; 8 Natural Products and Antifungal Drug Discovery; 9 Use of an Animal Model of Disseminated Candidiasis in the Evaluation of Antifungal Therapy; 10 Murine Model of Invasive Aspergillosis; 11 Antifungal Combinations; 12 Postantifungal Effect Methods; PART IV. HOST RESPONSES AND IMMUNOTHERAPY; 13 Evaluation of Immunotherapy in Invasive Candidiasis; 14 Interaction of Histoplasma capsulatum With Human Macrophages, Dendritic Cells, and Neutrophils Summary With the growing frequency of fungal infections even as resistance to existing antifungal agents increases, methods for finding novel drug targets and evaluating antifungal resistance have become more important than ever. In Antifungal Agents: Methods and Protocols, expert scientists describe in detail the state-of-the-art molecular methods they have optimized for studying antifungal resistance, for discovering and evaluating both new and existing antifungal drugs, and for understanding the host response and immunotherapy of such agents. Many of the protocols were developed in the laboratory and, when a method is limited to specific organisms, include alternative techniques to expand their application. The protocols follow the successful Methods in Molecular Medicine™ series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and highly practical, Antifungal Agents: Methods and Protocols offers clinician-scientists, microbiologists, and molecular biologists the productive tools they need today in order to understand and successfully develop new therapeutic agents for yeast, mold, and fungal infections Notes 15 Immunology of Infection Caused by Cryptococcus neoformansIndex Print version record Subject Antifungal agents -- Research -- Methodology Medical mycology -- Immunotherapy Mycoses. Drug resistance in microorganisms. Anti-infective agents. Candida. Biology. Life sciences. Fungi imperfecti. Drug resistance. Yeast fungi. Physical sciences. Diseases. Candida albicans. Candidiasis. Mycoses Drug Resistance, Microbial Anti-Infective Agents Investigative Techniques Candida Biology Therapeutic Uses Biological Science Disciplines Analytical, Diagnostic and Therapeutic Techniques and Equipment Mitosporic Fungi Bacterial Infections and Mycoses Drug Resistance Microbiological Phenomena Yeasts Fungi Phenomena and Processes Pharmacological Phenomena Natural Science Disciplines Disease Pharmacologic Actions Eukaryota Physiological Phenomena Disciplines and Occupations Chemical Actions and Uses Organisms Chemicals and Drugs Drug Resistance, Fungal Candida albicans Antifungal Agents Genetics Candidiasis Models, Animal biology. biological sciences. physical sciences. Yeast fungi Physical sciences Life sciences Fungi imperfecti Drug resistance in microorganisms Drug resistance Diseases Candidiasis Candida albicans Candida Biology Anti-infective agents Mycoses Form Electronic book Author Ernst, Erika J ISBN 9781592599431 1592599435

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