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Title Anticoagulation therapy / Joe F. Lau, Geoffrey D. Barnes, Michael B. Streiff editors
Published Cham, Switzerland : Springer, [2018]


Description 1 online resource (xxix, 452 pages) : illustrations, portraits
Contents Intro; Preface; Acknowledgments; Abbreviations; Contents; 1: Introduction; Anticoagulation Therapy: A Historical Perspective; The Evolving Anticoagulant Armamentarium; Resources for Anticoagulation Management; Exploring the Future of Anticoagulation Care; References; Part I: Anticoagulants; 2: Warfarin; Introduction; Pharmacology; Mechanism of Action; Pharmacokinetics; Absorption; Distribution; Metabolism; Elimination; Pharmacodynamics; Clinical Utility; Practical Management; Patient Engagement and Education; Dosing: Initiation; Dosing: Maintenance; Administration; Monitoring
Transitioning Between Warfarin and Other AnticoagulantsManagement of Warfarin Around Elective Procedures; Adverse Effects; Skin Necrosis; Purple Toe Syndrome; Other Adverse Effects; Bleeding; Reversal; INR Derangements in Asymptomatic Patients; INR 9; Bleeding Events; Nonmajor Bleeding; Major Bleeding; Urgent or Emergent Procedures; Special Considerations; Pregnancy; Breastfeeding; Pediatric Patients; Conclusion; References; 3: Unfractionated Heparin and Low-ƯMolecular-ƯWeight Heparin; Introduction; Unfractionated Heparin; Pharmacokinetics and Pharmacodynamics
Clinical Indications and DosingMonitoring; Considerations in Special Populations; Obesity; Pregnancy; Strategies for Reversal of Unfractionated Heparin; Complications; Heparin Resistance; Osteopenia; Heparin-Induced Thrombocytopenia; Low-Molecular-Weight Heparin; Pharmacodynamics; Pharmacokinetics; Clinical Indications and Dosing; Considerations in Special Populations; Obesity; Renal Dysfunction and Elderly Patients; Pregnancy; Strategies for Reversal of Low-ƯMolecular-ƯWeight Heparins; Summary; References; 4: Parenteral Anticoagulants: Direct Thrombin Inhibitors and Pentasaccharides
Parenteral Direct Thrombin Inhibitors (Argatroban and Bivalirudin)Pharmacology; Mechanism of Action; Pharmacokinetics; Absorption; Distribution; Metabolism; Elimination; Pharmacodynamics; Clinical Utility; Heparin-Induced Thrombocytopenia (HIT); Argatroban; Bivalirudin; Coronary Reperfusion; Percutaneous Coronary Intervention (PCI) in Patients without HIT; Argatroban; Bivalirudin; Percutaneous Coronary Intervention (PCI) in Patients with HIT; Argatroban; Bivalirudin; Acute Myocardial Infarction (NSTEMI or STEMI) in Patients Who Cannot Undergo PCI; CABG with or Without HIT
Practical ManagementDosing; Administration; Monitoring and Titration; HIT; Coronary Reperfusion; Argatroban; Bivalirudin; Transitioning to Oral Anticoagulation; HIT; Argatroban; Bivalirudin; Coronary Reperfusion; Other Clinical Uses; Continuous Renal Replacement Therapy; ECMO; Adverse Effects; Reversal; Special Considerations; Pregnancy; Breastfeeding; Pediatric; Fondaparinux; Pharmacology; Mechanism of Action; Pharmacokinetics; Absorption; Distribution; Metabolism; Elimination; Renal Function; Age; Low Body Weight; Pharmacodynamics; Clinical Utility; Prevention of VTE; Orthopedic Surgery
Summary This book presents the latest evidence and guidelines supporting the use of anticoagulant therapy for various clinical scenarios. The field of anticoagulation therapy is evolving rapidly, particularly since the arrival and widespread adoption of direct oral anticoagulants. Organized in two parts, this book reviews the pharmacologic properties of various anticoagulants and details the clinical applications of anticoagulant therapy. Drugs such as warfarin and unfractionated heparin, as well as parenteral and direct oral anticoagulants are discussed in terms of their pharmacokinetics, drug-disease interactions, dosing strategies, and risk considerations. Clinical applications of anticoagulant therapy in disorders such as acute coronary syndromes, atrial fibrillation, and thrombophilia and in special populations such as pregnant women, the elderly, and in the patient with cancer are highlighted. Clinical vignettes, algorithms, clinical pearls, and self-assessment questions are integrated throughout the book. Featuring contributions from authorities in the field, Anticoagulation Therapy is an essential resource for cardiologists, vascular medicine specialists, hematologists, internists, and all other healthcare professionals who prescribe anticoagulants
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Anticoagulants (Medicine)
Anticoagulants (Medicine) -- Therapeutic use
Anticoagulants -- therapeutic use
MEDICAL -- Pharmacology.
Anticoagulants (Medicine)
Anticoagulants (Medicine) -- Therapeutic use
Form Electronic book
Author Lau, Joe F., editor.
Barnes, Geoffrey D., editor.
Streiff, Michael B., editor.
ISBN 9783319737096