Thoughts on the nature of medical controversy in general and an overview of the cholesterol controversy in particular -- Animal models of atherosclerosis -- Early evidence linking hypercholesterolemia to atherosclerosis and coronary heart disease -- Lipoproteins and metabolism -- In search of a pathogenesis -- Basic science foundations -- Searching for drugs that would lower blood cholesterol safely and effectively -- 1984 coronary primary prevention trial -- Statins -- A look at the future
Summary
Presents an analytic history of a major controversy in biomedical research and the lessons it offers in dealing with future controversies
