Title Carcinogenic and anticarcinogenic food components / edited by Wanda Baer-Dubowski, Agnieszka Bartoszek, Danuta Malejka-Giganti

Published Boca Raton, FL : Taylor & Francis, 2006

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Description 1 online resource (393 pages) : illustrations Series Chemical and functional properties of food components series Chemical and functional properties of food components series. Contents Front cover; Preface; The Editors; Contributors; Contents; 1; Food and Cancer: Development of an Association; 1.1 Historical Background; 1.2 Nutritional Needs; 1.3 Carcinogenic Potential of Food; 1.4 Anticarcinogenic Activity of Food; 1.5 Genetically Determined Variability of Cancer Risk; 1.6 Epidemiologic Evidence for an Association between Nutrition and Cancer; 1.7 Final Remarks; References; 2; Molecular Mechanisms of Carcinogenesis; 2.1 Introduction; 2.2 Multistage Process of Carcinogenesis; 2.2.1 Molecular Mechanisms of Mutagenesis and Carcinogenesis; 2.2.1.1 Role of DNA Damage 2.2.1.2 Protooncogenes and Tumor Suppressor Genes: Regulators of Cell Growth2.2.2 Molecular and Cellular Events during Initiation and Promotion of Carcinogenesis; 2.2.2.1 Activation of Oncogenes; 2.2.2.2 Inactivation of Tumor Suppressor Genes; 2.2.2.3 Alteration of Genes Regulating Apoptosis; 2.2.3 Molecular and Cellular Events during Progression of Carcinogenesis; 2.3 Dietary Initiators and Promoters of Carcinogenesis in Humans; 2.3.1 Examples of Dietary Initiators; 2.3.2 Examples of Dietary Promoters; 2.4 Endogenous DNA Damage; 2.5 Concluding Remarks; References; 3 Metabolism of Chemical Carcinogens3.1 Introduction; 3.2 Enzymatic Systems Involved in Metabolism of Carcinogens; 3.2.1 Cytochromes P450; 3.2.2 Other Carcinogen-Metabolizing Enzymes; 3.2.2.1 UDP-Glucuronosyl Transferases (UDPGT; EC 2.4.1.17); 3.2.2.2 Sulfotransferases (SULT; EC 2.8.2); 3.2.2.3 Glutathione S-Transferases (GST; EC 2.5.1.18); 3.2.2.4 N-acetyltransferases (NAT; EC 2.3.1.5); 3.2.2.5 Microsomal Epoxide Hydrolase (mEH; EC 3.3.2.3); 3.2.3 The Role of Enzymes of the Intestinal Microflora in Bioactivation of Foodborne Carcinogens; 3.2.4 Concluding Remarks 3.3 Metabolic Pathways of Selected Foodborne Carcinogens3.3.1 Polycyclic Aromatic Hydrocarbons (PAHs); 3.3.2 Aflatoxin B1 (AFB1); 3.3.3 Heterocyclic Aromatic Amines (HAAs); 3.3.4 N-nitrosamines; 3.4 Concluding Remarks; References; 4; Genotoxic Food Components; 4.1 Introduction; 4.2 Genotoxicity in Risk Assessment of Diet-Related Carcinogenic Factors; 4.3 Genotoxic Food Components; 4.3.1 Mycotoxins; 4.3.2 N-Nitroso Compounds; 4.3.3 Polycyclic Aromatic Hydrocarbons; 4.3.4 Heterocyclic Aromatic Amines; 4.3.5 Acrylamide; 4.3.6 Miscellaneous Foodborne Genotoxic Agents 4.4 Products of Oxidative Processes4.4.1 Reactive Oxygen Species with DNA-Damaging Potential; 4.4.2 Genotoxic Products of Lipid Peroxidation; 4.5 Conclusions; References; 5; Impact of Food Preservation, Processing, and Cooking on Cancer Risk; 5.1 Introduction; 5.2 Preservation and Processing; 5.2.1 Salted Foods; 5.2.2 Nitrates (V)/(III) and N-Nitroso Compounds (NOCs); 5.2.3 Smoked Foods -- Polycyclic Aromatic Hydrocarbons (PAHs); 5.3 Cooking Methods; 5.3.1 Heterocyclic Aromatic Amines (HAAs); 5.3.2 Polycyclic Aromatic Hydrocarbons (PAHs); 5.3.3 Acrylamide; 5.4 Conclusions; References; 6 Summary Food and Cancer: Development of an Association, K. (Chris) Szyfter and J. GaweckiMolecular Mechanisms of Carcinogenesis, Danuta Malejka-Giganti and Natalia TretyakovaMetabolism of Chemical Carcinogens, Zofia MazerskaGenotoxic Food Components, Agnieszka BartoszekImpact of Food Preservation, Processing, and Cookingon Cancer Risk, Amanda J. Cross and Rashmi SinhaEnvironmental Contamination of Food, Marek Biziuk and Agnieszka BartoszekDietary Anti- and Prooxidants: Their Impact on OxidativeDNA Damage and Cancer Risk, Ryszard Olinski, Daniel Gackowski Marcus S. Cooke, and Joe LunecDietary Polyunsat Bibliography Includes bibliographical references and index Notes Print version record Subject Carcinogens. Food -- Toxicology. Functional foods. Cancer -- Diet therapy. Diet therapy. Neoplasms -- prevention & control Anticarcinogenic Agents Carcinogens Diet Therapy Food -- adverse effects Neoplasms -- chemically induced Nutrition Therapy MEDICAL -- Oncology. HEALTH & FITNESS -- Diseases -- Cancer. Diet therapy Cancer -- Diet therapy Carcinogens Food -- Toxicology Functional foods Form Electronic book Author Baer-Dubowska, Wanda Bartoszek, Agnieszka Malejka-Giganti, Danuta ISBN 1420039261 9781420039269 9780849320965 0849320968

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