Title Molecular neurosurgery with targeted toxins / edited by Ronald G. Wiley and Douglas A. Lappi

Published Totowa, N.J. : Humana Press, ©2005

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Description 1 online resource (xi, 311 pages) : illustrations Contents Introduction to molecular neurosurgery / Ronald G. Wiley and Douglas A. Lappi -- Ribosome-inactivating proteins / Fiorenzo Stirpe -- Biochemical, physiological, and behavioral characterizations of the cholinergic basal forebrain lesion produced by 192 IgG-saporin / Jerene J. Waite -- Basal forebrain cholinergic lesion by 192 IgG-saporin: a tool to assess the consequences of cortical cholinergic dysfunction in Alzheimers disease / Reinhard Schliebs -- 192 IgG-saporin-induced partial cortical cholinergic deafferentation as a model for determining the interactions between brain aging and neurodevelopmental defects in the cortical cholinergic input system / Martin Sarter and John P. Bruno -- Exploring the role of acetylcholine in primate cognition using Me20.4 IgG-saporin / Rosalind M. Ridley and Harry F. Baker -- Cortical cholinergic deafferentation induces A-beta deposition: towards a physiologic animal model of Alzheimer's disease / Thomas G. Beach [and others] -- Chemical dissection of brain glucoregulatory circuitry / Sue Ritter [and others] -- Cardiovascular deficits after lesions of C1 adrenergic neurons with a saporin-based immunotoxin / Patrice G. Guyenet, Ruth L. Stornetta, and Ann M. Schreihofer -- Saporin conjugates and pain / Ronald G. Wiley and Douglas A. Lappi -- The use of saporin conjugates to dissect neurons responsible for sleep and wakefulness / Carlos Blanco-Centurion [and others] -- Isolectin I-B4-mediated cytotoxic targeting of sensory neurons / Lucy Vulchanova and Christopher N. Honda -- B fragment of cholera toxin conjugated to saporin / Peter T. O'hara, Kanwarjit Kelley, and Luc Jasmin Summary "The use of targeted cytotoxins to make highly selective neural lesions for both experimental and clinical purposes has already provided important animal models for diseases such as Alzheimer's, and holds great promise for research and clinical application to pain. In Molecular Neurosurgery With Targeted Toxins, pioneers in the field describe their hands-on experience with the experimental use of these toxins. The authors focus on the highly successful use of the immunotoxins, 192 IgG-saporin and ME20.4-saporin, to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals." "Both practical and theoretical, Molecular Neurosurgery With Targeted Toxins provides readers with not only the background to understand these techniques, but also numerous real life examples that can be readily adapted to new purposes and an ever-increasing number of new targeted toxins."--Jacket Bibliography Includes bibliographical references and index In Springer e-books Subject Neurotoxic agents -- Therapeutic use Drug targeting. Antibody-toxin conjugates -- Therapeutic use Antibody-toxin conjugates. Immunotoxins -- therapeutic use Antibodies, Monoclonal -- therapeutic use Cholinergic Fibers -- metabolism Neurobiology -- methods Neurons -- pathology Drug Delivery Systems Immunoconjugates Immunotoxins HEALTH & FITNESS -- Diseases -- Nervous System (incl. Brain) MEDICAL -- Neurology. Drug targeting. Antibody-toxin conjugates -- Therapeutic use. Immunotoxins -- therapeutic use. Antibodies, Monoclonal -- therapeutic use. Cholinergic Fibers -- metabolism. Neurobiology -- methods. Neurons -- pathology. Neurotoxic agents -- Therapeutic use. Antibody-toxin conjugates Drug targeting Form Electronic book Author Wiley, Ronald G., 1947- Lappi, Douglas A ISBN 1588291995 9781588291998 159259896X 9781592598960 1280358157 9781280358159

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