| Description |
1 online resource |
| Contents |
Introduction -- Translational considerations and challenges : an overview -- Considerations for construct and affinity design goals -- Epitope characterization and isotype selection -- Biophysical considerations for development of antibody-based therapeutics -- Novel technologies for generation of bispecific constructs -- Stimulus-response mechanisms : an overview -- Evaluation of tumor growth inhibition in preclinical tumor models : a quantitative approach -- Application of proof-of-mechanism biomarkers (POM) in design and development of biologics modalities -- Antibody drug conjugates : translational considerations -- Application of PK-PD modeling and simulation approaches for immuno-oncology drugs -- Translational biomarkers : application in the clinical development of combination therapies -- Correction to : considerations for construct and affinity design goals |
| Summary |
This book examines vital considerations in designing effective translational strategies in the development of antibody-based therapeutics, including the relationship between the 'unit dose' and 'unit effect' with respect to beneficial and deleterious effects |
| Bibliography |
Includes bibliographical references |
| Notes |
Online resource; title from PDF title page (EBSCO, viewed September 20, 2018) |
| Subject |
Monoclonal antibodies -- Therapeutic use
|
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Antibodies, Monoclonal -- pharmacology
|
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Antibodies, Monoclonal -- therapeutic use
|
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Antigens -- immunology
|
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Drug Discovery
|
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Translational Research, Biomedical
|
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Pharmacology.
|
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Biochemistry.
|
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Pharmacy -- dispensing.
|
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MEDICAL -- Pharmacology.
|
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Monoclonal antibodies -- Therapeutic use
|
| Form |
Electronic book
|
| Author |
Tabrizi, Mohammad A., editor
|
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Bornstein, Gadi G., editor
|
|
Klakamp, Scott L., editor
|
| ISBN |
9789811304965 |
|
9811304963 |
|
