Limit search to available items
Book Cover
E-book

Title New drugs and targets for asthma and COPD / volume editors, Trevor T. Hansel, Peter J. Barnes
Published Basel : Karger, ©2010

Copies

Description 1 online resource
Series Progress in respiratory research, 1422-2140 ; v. 39
Progress in respiratory research ; v. 39.
Contents Cover; Contents; Corresponding authors; Foreword; Preface; Introduction; New drugs and targets for asthma and COPD; Introduction; New bronchodilators; New corticosteroids; Mediator antagonists; IgE-directed therapy; Immunotherapy and microbial products; Cytokine-directed therapy; Chemokine receptor antagonists; Adhesion molecule blockade; Phosphodiesterase inhibitors; Antagonists of oxidants, mucus, proteases and fi brosis; Treating concomitant conditions; Reversal of corticosteroid resistance: theophylline; Transcription-factor and kinase inhibition
Nucleic acid therapy: Antisenseoligodeoxynucleotidesand interference RNALung regeneration: Retinoic acid and stem cellsSince a major mechanism of airway obstruction; Conclusions; References; Bronchodilators; Indacaterol: A new once-daily long-acting beta2-adrenoceptor agonist (LABA); Introduction; Pharmacology and preclinical data; Clinical data; Efficacy; Other endpoints; Safety/tolerability; Summary and outlook; References; Aclidinium bromide, a novel long-acting muscarinic antagonist (LAMA)a; The target; Preclinical pharmacology; Clinical studies; References
Dual-pharmacology bronchodilators for the treatment of COPDlateThe targets; Pharmacology; Conclusions and future perspectives; References; IgE- and epithelial-directed approaches; IgE-directed approaches: A general strategy for the treatment of atopic diseaseslate; The target; The drugs: Therapeutic anti-Ig Emonoclonal antibodies; Preclinical pharmacology; Human clinical studies; References; Therapy directed against thymic stromal lymphopoietin (TSLP); The target; Therapeutic approaches; Key questions for future therapy; References; T-cell co-stimulator blockade
ICOS and B7RP-1: Novel targets for monoclonal antibodieslateThe targets; The drugs; Preclinical pharmacology; Human clinical data; References; Pattern recognition receptors; Toll-like receptor 2 as therapeutic target in lung diseaseate; The target; TLR2 expression; Role of TLR2 in health and disease; Evidence for a role for TLR2 in lung disease; The tools; Summary and conclusions; References; Toll-like receptor 3late; Introduction: TLRs and innate immunity; Biochemistry: TLR3 pathway; Function of TLR3; TLR3 in human diseases; Therapeutic approaches; References; Toll-like receptor 4late
The targetPharmacology; Human data; References; Toll-like receptor 7 and 8 agonistse; The target; The drugs; Preclinical pharmacology-in vivo studies; Human clinical data; References; Toll-like receptor 9 activation with CpG oligodeoxynucleotides for asthma therapylate; Preclinical pharmacology; Human clinical data; References; Cytokines; IL-5-directed approaches in the treatment of eosinophil-driven diseaselate; The targets; Pharmacology; Pharmacokinetic profile; Preclinical animal models; Human clinical studies; Conclusions; References
Summary "Asthma, allergy and chronic obstructive lung disease are common throughout the world and are increasing in incidence, particularly in the developing world. This volume provides a state-of-the-art account of the identification of new targets and the development of new therapies for these conditions. Some 40 chapters by clinical academics and senior members of the pharmaceutical industry detail the latest breakthroughs in research and development. In asthma, a promising approach is the use of therapy directed against specific Th2 responses through biological antagonists of IL-5, IL-4 and IL-13. There have also been major advances in our understanding of innate immune responses to pathogen-associated molecular patterns, and in the area of Toll-like receptors. Up to date and comprehensive, this book will be of particular relevance to those working in the pharmaceutical industry (in preclinical research and clinical development), to academic researchers in the field of respiratory medicine, and to respiratory health care specialists."--Publisher's website
Bibliography Includes bibliographical references and index
Subject Asthma -- Chemotherapy.
Antiasthmatic agents.
Respiratory agents.
Asthma -- drug therapy
Pulmonary Disease, Chronic Obstructive -- drug therapy
Respiratory System Agents
Anti-Asthmatic Agents
HEALTH & FITNESS -- Diseases -- Respiratory.
MEDICAL -- Pulmonary & Thoracic Medicine.
Respiratory agents
Antiasthmatic agents
Asthma -- Chemotherapy
Form Electronic book
Author Hansel, T. T. (Trevor T.), 1956-
Barnes, Peter J., 1946-
S. Karger (Firm)
ISBN 9783805595674
3805595670
1283439344
9781283439343