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Title Chromosomal instability in cancer cells / B. Michael Ghadimi, Thomas Ried, editors
Published Cham : Springer, 2015


Description 1 online resource (vii, 224 pages) : color illustrations
Series Recent results in cancer research, 0080-0015 ; volume 200
Recent results in cancer research ; volume 200.
Contents DNA Repair and Chromosomal Translocations -- CINcere modelling: What have mouse models for chromosome instability taught us? -- Telomere Dysfunction, Chromosomal Instability and Cancer -- Genetic Instability and Disease Prognostication -- Causes of Chromosomal Instability -- Patterns of Chromosomal Aberrations in Solid Tumors -- Yeast as Models of Mitotic Fidelity -- The diverse effects of complex chromosome rearrangements and chromothripsis in cancer development -- Consequences of aneuploidy in cancer: transcriptome and beyond
Summary This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification
Bibliography Includes bibliographical references
Notes Online resource; title from PDF title page (SpringerLink, viewed September 25, 2015)
Subject Cancer cells.
Chromosome abnormalities.
Translocation (Genetics)
Chromosomal Instability -- genetics
Neoplasms -- genetics
Translocation, Genetic
Gene Expression Regulation, Neoplastic -- genetics
Chromosome Aberrations
Medical genetics.
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Cancer cells.
Chromosome abnormalities.
Form Electronic book
Author Ghadimi, B. Michael, editor
Ried, Thomas, editor.
LC no. 2015944746
ISBN 9783319202914