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Author Rasnick, David William, 1948-

Title The chromosomal imbalance theory of cancer : autocatalyzed progression of aneuploidy is carcinogenesis / David Rasnick
Published Enfield, NH : Science Publishers ; Boca Raton, FL : Distributed by CRC Press, ©2012


Description 1 online resource (xviii, 341 pages) : illustrations (some color)
Contents 1. Introducing Cancer -- 2. Boveri's theory of cancer was ahead of its time -- 3. Genesis of "The enemy within"? -- 4. Gene mutation theory of cancer -- 5. The chromosomal imbalance theory of cancer -- 6. Theory of chromosomal imbalance solves mysteries and paradoxes -- 7. New perspectives for cancer prevention, diagnosis and therapy
Summary Rasnick, who worked in the pharmaceutical/biotech industry to develop protease inhibitors and founded three biotech companies, explains the chromosomal imbalance (aneuploidy) theory of cancer, as opposed to the gene mutation theory. He describes how gene mutations are not powerful enough to cause cancer; how cancer is initiated and why progression takes years or decades; and the global or macroscopic characteristics that identify cancer: anaplasia, autonomous growth, metastasis, abnormal cell morphology, DNA indices from 0.5 to over 2, genetic instability, and the high level of membrane-bound and secreted proteins responsible for invasiveness and loss of contact inhibition. He explains the common failure of chemotherapy and why cancer cells often become drug resistant, measures for detecting cancer and monitoring its progression, and non-toxic strategies for therapy and prevention. Distributed by CRC Press. Annotation ©2012 Book News, Inc., Portland, OR (
Bibliography Includes bibliographical references (pages 240-316) and index
Subject Carcinogenesis.
Cancer -- Genetic aspects.
Neoplasms -- etiology
Neoplasms -- genetics
Chromosomal Instability
HEALTH & FITNESS -- Diseases -- Cancer.
MEDICAL -- Oncology.
Cancer -- Genetic aspects.
Form Electronic book
ISBN 9781466502499