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Book Cover
E-book
Author Flanagan, Robert J

Title Fundamentals of analytical toxicology
Edition 2nd edition
Published [Place of publication not identified] : John Wiley, 2016

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Description 1 online resource
Contents Cover -- Title Page -- Copyright -- Contents -- Preface -- Health and Safety -- Nomenclature, Symbols, and Conventions -- Uniform Resource Locators -- Amount Concentration and Mass Concentration -- Acknowledgements -- List of Abbreviations -- Section A The Basics -- Chapter 1 Analytical Toxicology: Overview -- 1.1 Introduction -- 1.2 Modern analytical toxicology -- 1.2.1 Analytical methods -- 1.2.2 Systematic toxicological analysis -- 1.2.3 Ethanol and other volatile substances -- 1.2.4 Trace elements and toxic metals -- 1.3 Provision of analytical toxicology services
1.3.1 Samples and sampling -- 1.3.2 Choice of analytical method -- 1.3.3 Method validation and implementation -- 1.3.4 Quality control and quality assessment -- 1.4 Applications of analytical toxicology -- 1.4.1 Clinical toxicology -- 1.4.2 Forensic toxicology -- 1.4.3 Testing for substance misuse -- 1.4.4 Therapeutic drug monitoring -- 1.4.5 Occupational and environmental toxicology -- 1.5 Summary -- References -- Chapter 2 Sample Collection, Transport, and Storage -- 2.1 Introduction -- 2.2 Clinical samples and sampling -- 2.2.1 Health and safety -- 2.2.2 Clinical sample types
2.2.3 Blood and blood fractions -- 2.2.3.1 Arterial blood -- 2.2.3.2 Venous blood -- 2.2.3.3 Serum -- 2.2.3.4 Plasma -- 2.2.3.5 Blood cells -- 2.2.3.6 Dried blood spots -- 2.2.3.7 Volumetric microsampling -- 2.2.4 Urine -- 2.2.5 Stomach contents -- 2.2.6 Faeces -- 2.2.7 Tissues -- 2.3 Guidelines for sample collection for analytical toxicology -- 2.3.1 Sample collection and preservation -- 2.3.2 Blood -- 2.3.2.1 Collection of blood post-mortem -- 2.3.3 Urine -- 2.3.4 Stomach contents -- 2.3.5 Oral fluid -- 2.3.6 Sweat -- 2.3.7 Exhaled air -- 2.3.8 Cerebrospinal fluid -- 2.3.9 Vitreous humour
2.3.10 Synovial fluid -- 2.3.11 Pericardial fluid -- 2.3.12 Intraosseous fluid -- 2.3.13 Liver -- 2.3.14 Bile -- 2.3.15 Other tissues -- 2.3.16 Insect larvae -- 2.3.17 Keratinaceous tissues (hair and nail) -- 2.3.18 Bone -- 2.3.19 Injection sites -- 2.3.20 Scene residues -- 2.4 Sample transport, storage, and disposal -- 2.5 Common interferences -- 2.6 Summary -- References -- Chapter 3 Basic Laboratory Operations -- 3.1 Introduction -- 3.1.1 Reagents and standard solutions -- 3.1.2 Reference compounds -- 3.1.3 Preparation and storage of calibration solutions
3.2 Aspects of quantitative analysis -- 3.2.1 Analytical error -- 3.2.2 Minimizing random errors -- 3.2.2.1 Preparation of a solution of known concentration -- 3.2.3 Accuracy and precision -- 3.2.3.1 Assessing precision and accuracy -- 3.2.3.2 Detecting systematic error (fixed bias) -- 3.2.3.3 Identifying sources of variation: analysis of variance -- 3.2.3.4 Measurement uncertainty -- 3.2.4 Calibration graphs -- 3.2.4.1 Linear regression -- 3.2.4.2 Testing for linearity -- 3.2.4.3 Weighted linear regression -- 3.2.4.4 Non-linear calibration -- 3.2.4.5 Residuals and standardized residuals
Subject Analytical toxicology.
Form Electronic book
ISBN 9781119122364
1119122368