| Description |
1 online resource (xix, 356 pages) |
| Contents |
2. Types of Errors in Instrumental Analysis -- 2.1. Overview -- 2.2. Random Errors -- 2.2.1. Distribution of Measured Values -- 2.2.2. Standard Deviation -- 2.2.3. Confidence Interval -- 2.2.4. Confidence Interval and Quality -- 2.2.5. Propagation of Errors -- 3. Statistical Tests -- 3.1. General Remarks -- 3.2. Tests for Series of Measurements -- 3.2.1. Rapid Test for Normal Distribution (David Test) -- 3.2.2. Test for a Trend -- 3.2.3. Test for Outliers -- 3.3.Comparison of Two Standard Deviations -- 3.4.Comparison of More than Two Standard Deviations -- 3.5.Comparison of Two Mean Values -- 3.6.Comparison of More than Two Mean Values: Analysis of Variance -- 4. General Aspects of Linear Regression -- 4.1. Correlation, Regression, and Calibration -- 4.2. Linear Calibration Model -- 4.3. Simplification of the Linear Calibration Function -- 4.4. Quadratic Regression Analysis -- 4.5. Working Range and Calibration Standards |
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5. Validation of Method Performance -- 5.1. General Remarks -- 5.2. Precision -- 5.3. Linearity of Calibration Lines -- 5.3.1. General Remarks -- 5.3.2. Quality Coefficient -- 5.3.3. Visual Examinations -- 5.3.4. Mandel Test -- 5.3.5. The Lack-of-Fit Test by ANOVA -- 5.3.6. Test of the Significance of the Quadratic Regression Coefficient a2 -- 5.4. Test for Outliers in the Linear Regression Function -- 5.5. Homogeneity of Variances -- 5.6. Weighted Linear Least Squares Regression -- 5.7. Tests for Trueness -- 5.7.1. Systematic Errors in the Least Squares Regression Procedure -- 5.7.2. Mean Value t-Test -- 5.7.3. Recovery Rate -- 5.7.4. Recovery Rate of Stocked Samples -- 5.7.5. Recovery Function -- 5.7.6. Standard Addition Procedure -- 5.7.7. Test by Method Comparison -- 5.7.8. Standard Addition Method -- 5.8. Limit of Detection and Limit of Quantification -- 5.9. Robustness, Ruggedness -- 5.10. Application of Method Validation |
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6. Aspects of Method Development -- 6.1. General Remarks -- 6.2. Selectivity and Specificity -- 6.3. Method Development of Headspace Gas Chromatography -- 7. Performance Verification of Analytical Instruments and Tools: Selected Examples -- 7.1. General Remarks on Qualification and Performance Verification of Laboratory Instruments -- 7.2. UV -- Vis Spectrophotometers -- 7.2.1. Wavelength Accuracy -- 7.2.2. Stray Light -- 7.2.3. Resolution -- 7.2.4. Photometric Accuracy -- 7.3. HPLC Instruments -- 7.4. Balances -- 8. Control Charts in the Analytical Laboratory -- 8.1. Quality Control -- 8.2. Shewhart Charts -- 8.3. CuSum Charts -- 9. Interlaboratory Studies -- 9.1. Purpose and Types of Interlaboratory Studies -- 9.2. Method Performance Studies -- 9.3. Proficiency Testing -- 10. Measurement Uncertainty -- 10.1. Purpose, Definitions, and Terminology -- 10.2. Steps in Measurement Uncertainty Estimation -- 10.3. Spreadsheet Method for Uncertainty Calculation -- 10.4. Procedure of the Nordtest Report |
| Summary |
Working in the lab, but unsure what your results actually mean? Would you like to know how to apply trueness tests, calculate standard deviations, estimate measurement uncertainties or test for linearity? This book offers you a problem-based approach to analytical quality assurance (AQA). After a short introduction into required fundamentals, various topics such as statistical tests, linear regression and calibration, tool qualification or method validation are presented in the form of exercises for self-study. Solutions are provided in a clear step-by-step manner. Interactive Excel-sheets are available as Extra Materials for trying out the various concepts. For professionals as well as graduate students confronted with analytical quality assurance for the first time, this book will be the clue to meeting such challenges |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
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Print version record |
| Subject |
Analytical chemistry -- Quality control
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SCIENCE -- Chemistry -- Analytic.
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Chimie.
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Science des matériaux.
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Analytical chemistry -- Quality control
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| Form |
Electronic book
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| Author |
Einax, J. (Jürgen)
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| ISBN |
9783642165955 |
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3642165958 |
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364216594X |
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9783642165948 |
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1283081938 |
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9781283081931 |
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9786613081933 |
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6613081930 |
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