Title Analgesia / contributors, F. Benedetti [and others] ; editor, Christoph Stein

Published Berlin ; New York : Springer, ©2007

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Description 1 online resource (viii, 435 pages) : illustrations Series Handbook of experimental pharmacology, 0171-2004 ; v. 177 Handbook of experimental pharmacology ; v. 177. 0171-2004 Contents Part I. Introduction -- Peripheral and central mechanism of pain generation / H.G. Schaible -- Part II. Drugs in clinical use -- Opioids / C. Zöllner, C. Stein -- Antipyretic analgesics: nonsteroidal antiinflammatory drugs, selective COX-2 inhibitors, paracetamol and pyrazolionones / B. Hinz, K. Brune -- Local anesthetics / R. Yanagidate, G.R. Strichartz -- Serotonin receptor ligands: treatments of acute migraine and cluster headache / P.J. Goadsby -- Anti-convulsants and anti-depressants / A.H. Dickenson, J. Ghandehari -- Part III. Compounds in preclinical development -- Neuropeptide and kinin antagonists / R.G. Hill, K.R. Oliver -- Glutamate receptor ligands / V. Neugebauer -- Adrenergic and cholinergic compounds / R.D. Sanders, M. Maze -- Cannabinoids and pain / I.J. Lever, A.S.C. Rice -- Part IV. Future targets in analgesia research -- Adenosine and ATP receptors / J. Sawynok -- Ion channels in analgesia research / J.N. Wood -- Protein kinases as potential targets for the treatment of pathological pain / R.R. Ji, Y. Kawasaki, Z.Y. Zhuang, Y.R. Wen, Y.Q. Zhang -- Part V. Pain Management beyond pharmacotherapy -- Placebo and endogenous mechanisms of analgesia / F. Bededetti -- Limitations of pharmacotherapy: behavioral approaches to chronic pain / H. Flor, M. Diers -- Subject index Summary Analgesics are among the oldest drugs described, albeit not necessarily for medicinaluse. Forexample, theSumeriansisolatedopioids(probablyfortheir euphoric effects) in the third millennium b. c. and the use of willow bark (salicin) for fever was?rst reported in the eighteenth century. Both types of drugs are still in use, but today they are supplemented by a wide array of substances ranging from antidepressants to ion channel blockers. Not all of theseareprescribedbyphysicians. Manycompoundsaresoldoverthecounter and thus available to the public for self-medication. As a result, analgesics are also the most misused class of drugs and are the culprit for a multitude of healthproblemsdueto untoward sideeffects. Thisvolumeattemptstosummarizethecurrentstateofknowledgeonme- anisms underlying the various effects of these drugs, their side effect pro?les, and their indications and contraindications in clinical use. It also gives - sights into current efforts to discover novel mechanisms underlying different types of pain generation and the resulting development of new modulating compounds. Theseefforts haveemergedmostlyas aconsequenceofthemore profound insights provided by molecular methods and of the now common use of animal models of pathological, rather than physiological, pain. These important issues are elaborated in the introductory chapter. In parallel, c- temporaryinterdisciplinarytreatmentapproacheshavetaughtusthatsomatic mechanisms alone cannot explain pain; it is an experience shaped as well by social context, memory, and other psychological phenomena. Thus, the book closes with two chapters putting pharmacological strategies into a broader perspective. All of these advancements culminate in the contemporary c- mon goal of developing mechanism-based rather than empiric approaches to thetreatment ofpain Analysis anesthesie anaesthesia neurologie neurology chirurgie surgery farmacologie pharmacology toxicologie toxicology psychologie psychology reumatiek rheumatism biomedische wetenschappen biomedicine Medicine (General) Geneeskunde (algemeen) Bibliography Includes bibliographical references and index Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL Print version record digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL Subject Analgesia. Analgesics. Pain -- Treatment. Analgesics -- pharmacokinetics Analgesics Analgesia Pain -- drug therapy MEDICAL -- Pain Medicine. Analgesics. Pain -- Treatment. Analgesics -- Pharmacokinetics. Analgesia. Pain -- drug therapy. Biomédecine. Sciences de la vie. Analgesia Analgesics Pain -- Treatment Analgetikum Form Electronic book Author Benedetti, F. (Fabrizio) Stein, Christoph, 1954- ISBN 9783540338239 3540338233 3540338225 9783540338222 6610745250 9786610745258

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