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Title Amyloid and related disorders : surgical pathology and clinical correlations / Maria M. Picken, Ahmet Dogan, Guillermo A. Herrera, editors
Published New York : Humana Press, ©2012


Description 1 online resource (xviii, 425 pages) : illustrations (some color)
Series Current clinical pathology
Current clinical pathology.
Contents Part 1. Introduction/General -- Aspects of the History and Nomenclature of Amyloid and Amyloidosis / Per Westermark -- Amyloid Diseases at the Molecular Level: General Overview and Focus on AL Amyloidosis / Mario Nuvolone, Giovanni Palladini and Giampaolo Merlini -- AA Amyloidosis / Amanda K. Ombrello and Ivona Aksentijevich -- The Hereditary Amyloidoses / Merrill D. Benson -- Dialysis-Associated Amyloidosis / Paweena Susantitaphong, Laura M. Dember and Bertrand L. Jaber -- Localized Amyloidoses and Amyloidoses Associated with Aging Outside the Central Nervous System / Per Westermark -- Cerebrovascular Amyloidoses / John M. Lee and Maria M. Picken
Part 2. Non-Amyloid Protein Deposits -- Differential Diagnosis of Amyloid in Surgical Pathology: Organized Deposits and Other Materials in the Differential Diagnosis of Amyloidosis / Guillermo A. Herrera and Elba A. Turbat-Herrera -- Light/Heavy Chain Deposition Disease as a Systemic Disorder / Guillermo A. Herrera and Elba A. Turbat-Herrera -- Non-Randall Glomerulonephritis with Non-organized Monoclonal Ig Deposits / Pierre Ronco, Alexandre Karras and Emmanuelle Plaisier -- Pathologies of Renal and Systemic Intracellular Paraprotein Storage: Crystalopathies and Beyond / Maria M. Picken
Part 3. Diagnosis -- Diagnosis of Amyloid Using Congo Red / Alexander J. Howie -- Diagnosis of Minimal Amyloid Deposits Using the Congo Red Fluorescence Method: A Review / Reinhold P. Linke -- Thioflavin T Stain: An Easier and More Sensitive Method for Amyloid Detection / Maria M. Picken and Guillermo A. Herrera -- Fat Tissue Analysis in the Management of Patients with Systemic Amyloidosis / Johan Bijzet, Ingrid I. van Gameren and Bouke P.C. Hazenberg -- Generic Diagnosis of Amyloid: A Summary of Current Recommendations and the Editorial Comments on Chaps. 12-15 / Maria M. Picken -- Routine Use of Amyloid Typing on Formalin-Fixed Paraffin Sections from 626 Patients by Immunohistochemistry / Reinhold P. Linke -- Amyloid Typing: Experience from a Large Referral Centre / Janet A. Gilbertson, Toby Hunt and Philip N. Hawkins -- Options for Amyloid Typing in Renal Pathology: The Advantages of Frozen Section Immunofluorescence and a Summary of General Recommendations for Immunohistochemistry (Chaps. 17-19) / Maria M. Picken -- Amyloid Typing: Immunoelectron Microscopy / Laura Verga, Patrizia Morbini, Giovanni Palladini, Laura Obici and Vittorio Necchi, et al. -- Classification of Amyloidosis by Mass Spectrometry-Based Proteomics / Ahmet Dogan
Part 4. Ancillary Studies of Amyloidosis -- Laboratory Support for Diagnosis of Amyloidosis / David L. Murray and Jerry A. Katzmann -- Bone Marrow Biopsy and Its Utility in the Diagnosis of AL Amyloidosis and Other Plasma Cell Dyscrasias / Sujata Ramamurthy, Lawreen H. Connors and Carl J. O'Hara -- Laboratory Methods for the Diagnosis of Hereditary Amyloidoses / S. Michelle Shiller, Ahmet Dogan, Kimiyo M. Raymond and W. Edward Highsmith
Part 5. Organ Involvement in Amyloidoses -- Amyloidoses of the Kidney and Genitourinary Tract / Maria M. Picken -- Cardiac Amyloidosis / Carmela D. Tan and E Rene Rodriguez -- Amyloidosis of the Gastrointestinal Tract and Liver / Oscar W. Cummings and Merrill D. Benson -- Peripheral Nerve Amyloidosis / Adam J. Loavenbruck, Janean K. Engelstad and Christopher J. Klein -- Clinical and Pathologic Issues in Patients with Amyloidosis: Practical Comments Regarding Diagnosis, Therapy, and Solid Organ Transplantation / Jay S. Dalal, Kevin Barton and Maria M. Picken -- Emerging Therapies for Amyloidosis / Merrill D. Benson -- Modern Therapies in AA Amyloidosis / Amanda K. Ombrello -- Medicolegal Issues of Amyloidosis / Timothy Craig Allen -- Amyloidosis from the Patient's Perspective / Muriel Finkel
Summary Annotation Abnormal proteins are known to be associated with various pathologies. Most notably, these include amyloidoses, monoclonal protein deposits associated with plasma cell dyscrasia/multiple myeloma, cryoglobulins and various related organized and non-organized deposits. Amyloid and Related Disorders presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. The rationale for various therapies, including transplantation, is discussed and tissue diagnosis (its pitfalls and strategies for avoiding them) and laboratory support are included. The involvement of all major organ systems including renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central nervous system, soft tissue and bone marrow pathology is covered. This approach provides a unifying concept of these pathologic processes, which have systemic involvement, and which have, hitherto, not been universally appreciated. Awareness of these diseases among a wider audience of pathologists may increase the rate of their diagnosis as well as that of earlier diagnosis. This volume will be invaluable to specialized and general pathologists as well as cytopathologists; other medical professionals may also benefit from this concise update on the systemic amyloidoses
Analysis Medicine
Internal medicine
Medicine & Public Health
Bibliography Includes bibliographical references and index
Notes English
Subject Amyloidosis.
Amyloidosis -- diagnosis
Amyloidosis -- pathology
Amyloidosis -- therapy
Amyloid -- adverse effects
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Form Electronic book
Author Picken, Maria M.
Doğan, Ahmet.
Herrera, Guillermo A., MD.
ISBN 9781607613893