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Title Abeta peptide and Alzheimer's disease : celebrating a century of research / Colin J. Barrow and David H. Small (eds.)
Published London : Springer, ©2007


Description 1 online resource (xi, 298 pages) : illustrations
Contents Cover -- Contents -- Preface -- Contributors -- 1. A Brief Introduction to the History of the -Amyloid Protein (A) of Alzheimer's Disease -- 2. The Acentric Pathway of Alzheimer's Disease -- 3. The Function of the Amyloid Precursor Protein Family -- 4. The Involvement of A in the Neuroinflammatory Response -- 5. Amyloid -Peptide(1-42), Oxidative Stress, and Alzheimer's Disease -- 6. Amyloid Toxicity, Synaptic Dysfunction, and the Biochemistry of Neurodegeneration in Alzheimer's Disease -- 7. A Variants and Their Impact on Amyloid Formation and Alzheimer's Disease Progression -- 8. Copper Coordination by -Amyloid and the Neuropathology of Alzheimer's Disease -- 9. Cholesterol and Alzheimer's Disease -- 10. Amyloid -Peptide and Central Cholinergic Neurons: Involvement in Normal Brain Function and Alzheimer's Disease Pathology -- 11. Physiologic and Neurotoxic Properties of APeptides -- 12. Impact of -Amyloid on the Tau Pathology in Tau Transgenic Mouse and Tissue Culture Models -- 13. Glial Cells and A Peptides in Alzheimer's Disease Pathogenesis -- 14. The Role of Presenilins in A-Induced Cell Death in Alzheimer's Disease -- 15. Immunotherapeutic Approaches to Alzheimer's Disease -- 16. Mouse Models of Alzheimer's Disease -- Subject Index -- Author Index -- Last Page
Summary Recent advances in genetics and brain biochemistry point to the Abeta peptide as the major culprit in causing neurodegeneration in Alzheimer's Disease (AD). This title is specifically targeted at summarizing current knowledge of the Abeta peptide and its role in AD. Written by leaders in the industrial and academic world specializing in this rapidly moving area, the book covers fundamental biochemical studies on this peptide, the genetic impact on Abeta expression and processing, and various AD therapeutic strategies that target Abeta. Although specifically focusing on the Abeta peptide and AD
Analysis geneeskunde
public health
humane genetica
human genetics
Medicine (General)
Geneeskunde (algemeen)
Bibliography Includes bibliographical references and indexes
Notes English
Print version record
In Springer e-books
Subject Amyloid beta-protein.
Alzheimer's disease -- Molecular aspects
Alzheimer's disease.
Alzheimer Disease -- etiology
Alzheimer Disease -- metabolism
Amyloid beta-Peptides -- metabolism
Amyloid beta-Peptides
Alzheimer Disease
HEALTH & FITNESS -- Diseases -- Alzheimer's & Dementia.
MEDICAL -- Neurology.
Alzheimer's disease -- Molecular aspects.
Alzheimer Disease -- etiology.
Alzheimer Disease -- metabolism.
Amyloid beta-Protein -- metabolism.
Amyloid beta-protein.
Alzheimer's disease
Alzheimer's disease -- Molecular aspects
Amyloid beta-protein
Form Electronic book
Author Barrow, Colin J.
Small, David H., 1956-
ISBN 9781846284403