Title Molecular biology of Alzheimer's disease : genes and mechanisms involved in amyloid generation / edited by Christian Haass

Published Amsterdam, the Netherlands : Harwood Academic Publishers, ©1998

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Description 1 online resource (xiii, 335 pages, 11 unnumbered pages of plates) : illustrations (some color) Contents Book Cover; Title; Contents; Contributors; Introduction; Amyloid Morphology and Pathology of Alzheimer's Disease; The Tau Proteins in Alzheimer's Disease; Mutations in Three Genes are Associated with Early Onset Alzheimer's Disease; The Biological Activities and Function of the Amyloid Precursor Protein of Alzheimer's Disease; Proteolytic Processing of the -Amyloid Precursor Protein; Biosynthesis of APP and A: Multiple Pathways for the Generation of Intracellular A; The Cell Biology of Amyloid Precursor Protein The Role of Amyloid -Peptide Terminating at Amino Acid 42 in Early Onset Alzheimer's DiseaseThe Biophysics of Amyloid -Protein Fibrillogenesis; The Molecular Biology of Presenilin 1; Molecular Biology of Presenilin 2; Presenilin Proteins and their Role in Development and Notch Signaling; The Processing of the Amyloid-Precursor-Protein (APP) in Presenilin-1 Deficient Neurons; Presenilins and their Role in Apoptosis; The Phosphorylation of Presenilin Proteins; APOE and its Role in Late Onset Alzheimer's Disease Transgenic Animal Models in the Development of Therapeutic Strategies for Alzheimer's DiseasePresenilins in Transgenic Mice; Index Summary Highlighting the latest and the most timely aspects of Alzheimer's disease research, this text will enable scientists in related research fields, as well as physicians working with Alzheimer's disease patients, to obtain a quick and complete overview of the current state of the art in one of the most exciting fields in neuroscience research. Leading scientists have contributed articles focusing on key developments in this field. This includes an overview about the pathology, the genetics of familial Alzheimer's disease, proteolytic generation and aggregation of amyloid -peptide, presenilins, r Bibliography Includes bibliographical references and index Notes English Print version record Subject Alzheimer's disease -- Genetic aspects Alzheimer's disease -- Molecular aspects Amyloid beta-protein precursor. Molecular neurobiology. Alzheimer Disease -- genetics Amyloid beta-Protein Precursor Amyloid beta-Peptides -- genetics Amyloid beta-Protein Precursor -- genetics HEALTH & FITNESS -- Diseases -- Alzheimer's & Dementia. MEDICAL -- Neurology. Alzheimer's disease -- Genetic aspects Alzheimer's disease -- Molecular aspects Amyloid beta-protein precursor Molecular neurobiology Form Electronic book Author Haass, Christian ISBN 020330361X 9780203303610 148228345X 9781482283457 1280053399 9781280053399 9786610053391 6610053391 0429077793 9780429077791

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