Title A paradigm shift to prevent and treat Alzheimer's disease : from monotargeting pharmaceuticals to pleiotropic plant polyphenols / Howard Friel and Sally Frautschy

Published London, United Kingdom : Academic Press, an imprint of Elsevier, 2017

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Description 1 online resource Contents 880-01 Monotargeting versus multitargeting -- The Pleiotropic pharmacology of plant polyphenols -- Primary prevention of Alzheimer's disease -- Secondary prevention of Alzheimer's disease -- Treatment mechanisms in mild to moderate Alzheimer's disease -- Pleiotropic theory -- Dose-adherence and intent-to-treat 880-01/(S GINKGO BILOBA EXTRACTREFERENCES; II -- Pleiotropism and Alzheimer's Disease; 3 -- Primary Prevention of Alzheimer's Disease; GINKGO BILOBA EXTRACTS (↑) ALPHA-SECRETASE (ADAM10); SAPPΑ; GREEN TEA EXTRACTS (↑) ALPHA-SECRETASE (ADAM10); SAPPΑ; OLIVE OIL EXTRACTS (↑) SAPPΑ; RED WINE (CABERNET SAUVIGNON) (↑) ALPHA-SECRETASE; CURCUMINOIDS (↓) BETA-SECRETASE (BACE-1); GINKGO BILOBA EXTRACTS (↓) BETA-SECRETASE; GREEN TEA EXTRACTS (↓) BETA-SECRETASE (BACE-1); CURCUMINOIDS (↓) GAMMA-SECRETASE (PRESENILIN-1); REFERENCES; 4 -- Secondary Prevention of Alzheimer's Disease; CURCUMINOIDS (↓) ABETA AGGREGATION Bibliography Includes bibliographical references and index Notes Online resource; title from PDF title page (ScienceDirect, viewed July 27, 2017) Subject Alzheimer's disease -- Chemotherapy Alzheimer's disease -- Prevention Alzheimer Disease -- drug therapy Alzheimer Disease -- prevention & control Molecular Targeted Therapy Plant Extracts -- therapeutic use Polyphenols -- therapeutic use HEALTH & FITNESS -- Diseases -- General. MEDICAL -- Clinical Medicine. MEDICAL -- Diseases. MEDICAL -- Evidence-Based Medicine. MEDICAL -- Internal Medicine. Alzheimer's disease -- Chemotherapy Alzheimer's disease -- Prevention Genre/Form Electronic books Form Electronic book Author Frautschy, Sally A., author. ISBN 9780128122792 012812279X 0128122595 9780128122594

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