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Book Cover
E-book
Author Khan, T. K

Title Biomarkers in Alzheimer's disease / T.K. Khan
Published London, United Kingdom : Academic Press : Elsevier, 2016

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Description 1 online resource
Contents Cover ; Title page; Copyright page; Contents; Foreword; Preface; Acknowledgments; Chapter 1 -- Introduction to Alzheimer's Disease Biomarkers ; 1.1 -- Historical Background; 1.2 -- Important Events in Alzheimer's Disease (AD) Research; 1.3 -- Some Facts About Alzheimer's Disease; 1.4 -- Common Features of Alzheimer's Disease; 1.5 -- Classification of Alzheimer's Disease; 1.6 -- Risk Factors for Alzheimer's Disease; 1.7 -- Definition of a Biomarker; 1.7.1 -- A. Categorization of Biomarkers According to Their Role
1.7.2 -- B. Definition of Common Statistical Parameters to Quantify the Performance of Biomarkers1.8 -- Biomarkers of Alzheimer's Disease; 1.9 -- Future Focus: Detecting Preclinical Stages of Alzheimer's Disease; 1.10 -- Economic Impact of Alzheimer's Disease Biomarkers; 1.11 -- Conclusions; Bibliography; Chapter 2 -- Clinical Diagnosis of Alzheimer's Disease ; 2.1 -- Clinical Diagnosis of Alzheimer's Disease: Historical Perspective; 2.2 -- Neuropsychological Assessment Tests to Diagnose Alzheimer's Disease; 2.2.1 -- Mini-Mental State Examination; 2.2.2 -- Clock Drawing Test
2.2.3 -- Alzheimer's Disease Assessment Scale2.2.4 -- Neuropsychological Test Battery; 2.2.4.1 -- Other neuropsychological tests; 2.2.5 -- Clinical Dementia Rating; 2.2.6 -- Global Deterioration Scale; 2.2.7 -- Dementia Severity Rating Scale; 2.3 -- Neuropathology at Brain Autopsy to Diagnose Alzheimer's Disease; 2.4 -- Accuracy of Clinical Diagnosis of Alzheimer's Disease; 2.5 -- Alzheimer's Disease-Related Neurological Conditions; 2.5.1 -- Preclinical Alzheimer's Disease; 2.5.2 -- Mild Cognitive Impairment; 2.5.3 -- Non-Alzheimer's Dementias; 2.5.3.1 -- Vascular dementia; 2.5.3.2 -- Lewy body dementia
2.5.3.3 -- Frontotemporal dementia2.5.3.4 -- Creutzfeldt-Jacob disease; 2.5.3.5 -- Other non-AD dementias; 2.6 -- Challenges in Diagnosing Alzheimer's Disease; 2.6.1 -- Long Prodromal Stages; 2.6.2 -- Comorbidity With Non-Alzheimer's Disease Dementias; 2.6.3 -- Multiple Nongenetic and Genetic Factors; 2.6.4 -- Anomalous Alzheimer's Disease Neuropathology; 2.7 -- Comprehensive Alzheimer's Disease Diagnostic Framework; 2.8 -- Conclusions; Bibliography; Chapter 3 -- Neuroimaging Biomarkers in Alzheimer's Disease ; 3.1 -- Neuroimaging in Alzheimer's Disease; 3.1.1 -- Structural Neuroimaging
3.1.2 -- Functional Neuroimaging3.1.3 -- Molecular Neuroimaging; 3.2 -- Common Neuroimaging Alzheimer's Disease Biomarkers and Modalities; 3.3 -- Magnetic Resonance Imaging; 3.3.1 -- Structural MRI; 3.3.2 -- Functional MRI; 3.3.3 -- Magnetic Resonance Spectroscopy; 3.3.4 -- Advanced Magnetic Resonance Based Neuroimaging Modalities; 3.3.4.1 -- Diffusion tensor imaging; 3.3.4.2 -- Arterial spin labeling MRI; 3.3.4.3 -- Task free fMRI; 3.4 -- Positron Emission Tomography; 3.4.1 -- Amyloid Imaging by PET; 3.4.2 -- Glucose Metabolism Measurement by PET; 3.4.3 -- Brain Inflammation Imaging by PET
3.4.4 -- Tau Imaging by PET
Notes Includes index
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Alzheimer's disease -- Molecular aspects
Biochemical markers.
Alzheimer Disease -- diagnosis
Biomarkers
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Alzheimer's disease -- Molecular aspects
Biochemical markers
Form Electronic book
LC no. 2017287347
ISBN 0128051477
9780128051474