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Author International Symposium on Cholinergic Mechanisms (11th : 2002 : St. Moritz, Switzerland)

Title Cholinergic mechanisms : function and dysfunction / edited by Israel Silman [and others]
Published London ; New York : Taylor & Francis, 2004


Description 1 online resource (lxiv, 774 pages) : illustrations
Contents Front Cover -- Cholinergic Mechanisms: Function and Dysfunction -- Copyright Page -- Contents -- Preface -- List of contributors -- Platform presentations -- Edith Heilbronn Lecture -- 1. In memoriam: Edith Heilbronn -- Nicotinic receptors: structure -- 2. Nicotinic acetylcholine receptors: probing functionally significant structural changes with site-directed reactions -- 3. The binding site for Î"-bungarotoxin in the acetylcholine receptor: from synthetic peptides to solution and crystal structure
4. Pharmacological and structural characterization of the interaction of snake toxins with nicotinic acetylcholine receptors5. Structure and dynamics of acetylcholine receptor and its lipid microenvironment: from molecule to cell -- 6. Site-directed reactive probes for structural and functional investigation of cholinergic proteins -- 7. The mechanism for acetylcholine receptor inhibition by Î"-neurotoxins and species-specific resistance to Î" -bungarotoxin revealed by NMR -- Muscarinic receptors: structure -- 8. Structure and activation of muscarinic acetylcholine receptors
9. Generation and analysis of muscarinic acetylcholine receptor knockout mice10. Roles of external loops of muscarinic receptors in interactions between N-methylscopolamine and allosteric modulators -- Couteaux lecture -- 11. Rene Couteaux (1909�1999) and his presynaptic active zone -- 12. René Couteaux Lecture: Ligand recognition in the cholinergic nervous system analysed by structural templates and protein dynamics -- Presynaptic mechanisms -- 13. Neuronal calcium dynamics: one message with many meanings
14. Acetylcholine- and glutamate-mediated transmission: one mediatophore with different specificities, or several mediatophores?15. The Ca-voltage hypothesis for neurotransmitter release � current status -- Structural and regulatory aspects of the cholinergic synapse -- 16. The role of P2Y1 nucleotide receptors in the formation and maintenance of the skeletal neuromuscular junctions -- 17. Control of expression of nicotinic receptor and acetylcholinesterase in the developing neuromuscular junction in the human muscle
18. The molecular neurobiology of acetylcholinesterase variants: from stressful insults to antisense intervention19. Transcriptional control of the cholinergic gene locus: a mosaic model for regulation of the cholinergic phenotype -- 20. Regulation of cholinergic gene expression by NRSF/REST -- 21. Unveiling the molecular events leading to a neurotransmitter phenotype switch in developing neurons -- Miriam Salpeter Lecture -- 22. Miriam M Salpeter (Mika) � biographical notes -- 23. Chemical kinetics parameters and receptor degradation rates at the neuromuscular junction
Summary The triennnial symposium on cholinergic mechanisms provides a key multidisciplinary forum for their interaction, and the proceedings of the XIth ISCM provide a cutting edge profile of research progress in this important field of research
Notes "A Martin Dunitz Book."
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Cholinergic mechanisms -- Congresses
Alzheimer's disease -- Congresses
Autoimmune diseases -- Congresses
Alzheimer's disease.
Autoimmune diseases.
Receptors, Cholinergic -- physiology
Alzheimer Disease
Autoimmune Diseases
Synaptic Transmission -- physiology
MEDICAL -- Neuroscience.
PSYCHOLOGY -- Neuropsychology.
Alzheimer's disease.
Autoimmune diseases.
Cholinergic mechanisms.
Genre/Form Conference papers and proceedings.
Conference papers and proceedings.
Actes de congrès.
Form Electronic book
Author Silman, Israel.
ISBN 0203493877