| Description |
1 online resource (xvi, 280 pages) : illustrations |
| Series |
ISOA Annual Investigators Meeting |
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ISOA Annual Investigators Meeting
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| Contents |
1. The Challenges of Drug Discovery and Drug Development for Cognitive Aging and Alzheimer's Disease / Howard Fillit and Alan O'Connell -- pt. I. Early Detection -- 2. Genetic Correlates of Successful Cognitive Aging / Thomas Perls -- 3. Genetic and Environmental Risk Factors for Alzheimer's Disease in Arabs Residing in Israel / Robert P. Friedland, Amos Korczyn and Lindsay Farrer -- 4. Telephonic Screening of Mental Status: A Feasibility Study in a Managed Care Clinic / David Knopman, Thomas Vonsternberg and Jim Haefemeyer -- 5. Use of Brain MRI Volumetric Analysis in a Mild Cognitive Impairment Trial to Delay the Diagnosis of Alzheimer's Disease / Michael Grundman, Drahomira Sencakova and Clifford R. Jack, Jr. / [and others] -- 6. Hippocampal Volume Assessment in Mild Cognitive Impairment / Michael S. Mega, Paul M. Thompson and Arthur W. Toga / [and others] -- 7. Brain Imaging Surrogate Markers for Detection and Prevention of Cognitive Aging and Alzheimer's Disease / Gary W. Small -- 8. Novel [beta]-Amyloid Probes / Mei-Ping Kung, Zhi-Ping Zhuang and Catherine Hou / [and others] -- 9. Early Clinical and Biological Manifestations of Alzheimer's Disease: Implications for Screening and Treatment / Richard C. Mohs, Deborah Marin and Vahram Haroutunian -- pt. II. Drug Discovery -- 10. Identification of Brain-Expressed ABC Transporters That May Mediate Detachment of [beta]-Amyloid From Biological Membranes / Peter B. Reiner and Stephane Le Bihan -- 11. Targeting an RNA Structure in the Amyloid Precursor Protein Gene as a New Therapeutic Strategy for Alzheimer's Disease / Jack T. Rogers -- 12. Novel Tricyclic Pyrone Compounds Prevent Intracellular APP C99-Induced Cell Death / Lee-Way Jin, Duy H. Hua and Feng-Shiun Shie / [and others] -- 13. Novel Glycosaminoglycans as Antiamyloid Agents / Robert Kisilevsky and Walter A. Szarek -- 14. Strategies for Inhibiting Alzheimer's [gamma]-Secretase / Michael S. Wolfe -- 15. Phosphorylations of Tau and APP as Targets for Drug Discovery / John DeBernardis, Dan Kerkman and Cintia Vianna / [and others] -- 16. Estrogen and ApoE: Drug Discovery Implications / Jonathan D. Smith and Justine A. Levin -- 17. Structure-Based Functional Design of Agonists and Antagonists for AMPA-Subtype Glutamate Receptors / Ming-Ming Zhou, Harel Weinstein and Diomedes E. Logothetis / [and others] -- 18. Alzheimer's Therapeutics: Neurotrophin Small Molecule Mimetics / Stephen M. Massa, You-Mei Xie and Frank M. Longo -- pt. III. Drug Development -- Preclinical -- 19. Antioxidants in the Treatment of Alzheimer's Disease: Breakthrough Potential of Indole-3-Propionic Acid / Daniel G. Chain, Douglas Galasko and Eyal Neria / [and others] -- 20. AF150(S) and AF267B: M1 Muscarinic Agonists for Treatment and as Disease-Modifying Agents in Alzheimer's and Related Diseases / A. Fisher, Z. Pittel and R. Brandeis / [and others] -- 21. ABS-205: Effects on Cognition in Mature and Aged Rats / Ciaran M. Regan -- 22. Calpain Inhibitors: A Treatment of Alzheimer's Disease / Ottavio Arancio -- 23. Femtomolar-Acting Neuroprotective Peptides: Application for Inhibition of Alzheimer's Disease / Illana Gozes, Sharon Furman and Ruth A. Steingart / [and others] -- pt. IV. Drug Development -- Clinical -- 24. A Phase I Clinical Study of Ex Vivo Nerve Growth Factor Gene Therapy for Alzheimer's Disease / Mark H. Tuszynski -- 25. Lowering Homocysteine Levels in Patients With Alzheimer's Disease / Paul Aisen, Mary Sano and Ramon Diaz-Arrastia / [and others] -- 26. Therapeutic Potential of Positive AMPA Receptor Modulators in Mild Cognitive Impairment and Alzheimer's Disease / Steven A. Johnson, Gary Lynch and Gary A. Rogers / [and others] -- 27. The Alzheimer's Disease Atorvastatin Treatment Trial: Scientific Basis and Position on the Use of HMG-CoA Reductase Inhibitors (Statins) That Do or Do Not Cross the Blood-Brain Barrier / D. Larry Sparks, Donald J. Connor and Patrick J. Browne / [and others] -- 28. A Double-Blind, Randomized Investigation of the Effects of Testosterone or Placebo in Male Patients With Mild-to-Moderate Alzheimer's Disease / Bruce Miller -- 29. Estrogen and Cognitive Functioning in Men With Mild Cognitive Impairment / Barbara B. Sherwin and Howard Chertkow |
| Summary |
This prestigious volume presents the findings of an international group of academic and biotechnological researchers. Topics range from early detection programs focusing on genetic factors, novel probes for detecting B-amyloid in the living brain, and the use of telephonic screening and MRI's to the diversity of therapeutic areas such as antioxidants, estrogen agonists and various anti-B-amyloid and anti-tangle approaches. The volume is still an indispensable resource for the psychogeriatrician, psychiatrist, clinical investigator, and neurobiologist, and a must for medical libraries |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL |
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Print version record |
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digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL |
| Subject |
Alzheimer's disease -- Chemotherapy -- Congresses
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Alzheimer's disease -- Chemotherapy -- Evaluation -- Congresses
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Drugs -- Testing -- Congresses
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Alzheimer Disease -- diagnosis
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Alzheimer Disease -- drug therapy
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Dementia -- drug therapy
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HEALTH & FITNESS -- Diseases -- Alzheimer's & Dementia.
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MEDICAL -- Neurology.
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Alzheimer's disease -- Chemotherapy
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Drugs -- Testing
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Alzheimerkrankheit
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Pharmakotherapie
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Nootropikum
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Pharmakologie
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| Genre/Form |
proceedings (reports)
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Conference papers and proceedings
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Conference papers and proceedings.
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Actes de congrès.
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| Form |
Electronic book
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| Author |
Fillit, Howard
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O'Connell, Alan W
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Institute for the Study of Aging.
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| LC no. |
2001049760 |
| ISBN |
9780826115348 |
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0826115349 |
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