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Title Alzheimer's disease : modernizing concept, biological diagnosis and therapy / volume editors, H. Hampel, M.C. Carrillo
Published Basel : Karger ; [Chicago, Ill.] : Alzheimer's Association, [2012]
©2012
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Description 1 online resource (200 pages) : illustrations
Series Advances in biological psychiatry, 0378-7354 ; v. 28
Advances in biological psychiatry ; v. 28. 0378-7354
Contents The global impact of Alzheimer's disease / M.C. Carrillo, W. Thies, L.J. Bain -- The genetics of Alzheimer's disease / M.C. Schu [and others] -- Current conceptual view of Alzheimer's disease / K. Herrup -- Neuropathological basis of Alzheimer's disease and Alzheimer's disease diagnosis / J.A. Schneider [and others] -- Diagnostic tools : fluid biomarkers for Alzheimer's disease / H. Zetterberg, H. Hampel, K. Blennow -- MRI-and PET-based imaging markers for the diagnosis of Alzheimer's disease / S. Teipel [and others] -- Changing diagnostic concepts of Alzheimer's disease / G.M. McKhann, M.S. Albert, R.A. Sperling -- Pharmacological treatment of Alzheimer's disease / L.S. Schneider -- Regulatory requirements on clinical trials in Alzheimer's disease / K. Broich [and others] -- Perspectives on Alzheimer's disease : past, present and future / Z.S. Khachaturian
Summary Expanding knowledge on genetic and epigenetic risk factors is rapidly enhancing our understanding of the complex molecular interactions and systems involved in the pathogenesis of Alzheimer's disease. In this publication, leading experts discuss emerging novel conceptual models of the disease along with advances in the development of surrogate markers that will not only improve the accuracy of diagnostic technologies but also improve the prospects of developing disease-modifying interventions. The novel framework of the disease presented here highlights research on biological markers as well as efforts to validate technologies for early and accurate detection. It also introduces notion of a complex systems dysfunction that extends beyond prevailing ideas derived from the 'amyloid' or 'tau' hypotheses. This outstanding publication provides researchers, clinicians, students and other professionals interested in neurodegenerative disorders with a comprehensive update on current trends and future directions in therapy development, with special focus on advances in clinical trial designs
Bibliography Includes bibliographical references and indexes
Notes Online resource; title from digital title page (ebrary, viewed on December 23, 2014)
Subject Alzheimer's disease -- Diagnosis
Alzheimer's disease -- Treatment
Alzheimer's disease.
Alzheimer Disease -- diagnosis
Alzheimer Disease
Alzheimer Disease -- therapy
Biomarkers -- metabolism
HEALTH & FITNESS -- Diseases -- Alzheimer's & Dementia.
MEDICAL -- Neurology.
Alzheimer's disease.
Alzheimer's disease -- Diagnosis.
Alzheimer's disease -- Treatment.
Alzheimer-Krankheit.
Diagnose.
Therapie.
Marker.
Form Electronic book
Author Hampel, H. (Harald), 1962- editor.
Carrillo, M. C. (Maria C.), editor.
Alzheimer's Association, issuing body.
ISBN 9783805598033
3805598033
9781280670909
1280670908