| Description |
1 online resource |
| Contents |
Cover -- The Biology of Multiple Sclerosis -- Title -- Copyright -- Contents -- Contributors -- Preface -- Chapter 1 Introduction: the biological basis -- History of discovery -- Characteristics of the disease -- Diagnosis -- Clinical signs -- Magnetic resonance imaging -- Autopsy -- Evidence for an environmental factor -- Nature of the environmental factor -- Viruses -- Vitamin D -- Evidence for a genetic factor -- Disease mechanisms -- Conclusion -- References -- Chapter 2 Neuropathology of multiple sclerosis -- Background -- Demyelinating disorders of the CNS -- History of MS pathology -- Pathological subtypes of MS -- Marburǵs disease -- Balo's concentric sclerosis -- Neuromyelitis optica -- Schildeŕs disease -- Tumefactive MS -- Acute disseminated encephalomyelitis -- Acute haemorrhagic leukoencephalopathy -- Multiple sclerosis -- MS: gross pathology -- Distribution of lesions -- Histopathology -- Demyelination -- Remyelination -- Neurodegeneration and axonal damage -- Oligodendrocyte damage -- Astrocytes -- Mitochondrial damage -- Stress proteins -- Lesion staging and evolution -- White matter lesions -- The pre-active lesion -- The active lesion -- The chronic active lesion -- The chronic inactive lesion -- Periplaque white matter -- Cortical grey matter pathology -- The type 1 lesion -- The type 2 lesion -- The type 3 lesion -- The type 4 lesion -- Deep grey matter -- Spinal cord -- The meninges -- Inflammation -- Innate immunity -- Microglia and macrophages -- Adaptive immunity -- T cells -- B cells -- Blood-brain barrier -- Conclusions -- Conflict of interest -- Acknowledgements -- References -- Chapter 3 Experimental autoimmune encephalomyelitis -- Background -- History of EAE -- Induction of EAE -- Adjuvants -- Autoantigens -- Immunisation protocols -- EAE protocol for ABH mice -- Clinical scoring -- Disease courses |
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Choice of model -- Mice -- Rats -- Guinea pigs -- Marmosets -- Rhesus macaques -- Pathology of EAE -- Localisation of lesions -- Demyelination -- Remyelination -- Oligodendrocyte damage and death -- Neurodegeneration and axonal damage -- Astrocyte pathology -- BBB and vascular damage -- Immune mechanisms -- Innate immunity -- Adaptive immunity -- Mutant and transgenic mouse models -- Guidelines for using, reporting, and reviewing EAE studies -- Materials and methods -- Results -- Conclusions -- Conflict of interest -- Acknowledgements -- References -- Chapter 4 Immunology of MS -- Introduction -- Tolerance and autoimmunity -- Pathogenesis of MS -- Myelin antigens -- Progression of MS -- Role of the innate immune system -- Dendritic cells -- Microglial cells and macrophages -- Natural killer cells and natural killer T cells -- gammadelta T cells -- The contribution of innate immunity during different stages of MS and EAE -- The role of the adaptive immune system in MS -- CD4+ T cells -- CD8+ T cells -- B cells -- Regulatory T cells -- Immunomodulatory therapies for MS -- First-line therapy for RRMS -- Second-line therapies for RRMS -- Emerging therapies -- SPMS and PPMS -- Summary -- References -- Chapter 5 Animal models based on virus infection -- Theiler's virus -- Determinants of disease -- Demyelination -- Semliki Forest virus -- Virulence determinants -- Demyelination -- JHM coronavirus -- Demyelination -- Relevance to MS -- Viruses as potential gene therapy agents in the treatment of MS -- Herpesvirus vectors -- Adenovirus vectors -- Retrovirus vectors -- Vaccinia virus vectors -- Alphavirus vectors -- Conclusions -- Acknowledgements -- References -- Chapter 6 Viruses in the etiology of MS -- Measles and rubella viruses -- Characteristics of the viruses -- Acute disseminated encephalomyelitis -- Measles inclusion body encephalitis |
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Subacute sclerosing panencephalitis -- Progressive rubella panencephalitis -- Link with MS? -- Herpesviruses -- Herpes simplex viruses type 1 and 2 -- Varicella-zoster virus -- Human herpesvirus type 6 -- Epstein-Barr virus -- Conclusions -- Retroviruses -- Association with MS -- Natalizumab and progressive multifocal leukoencephalopathy -- JC virus -- Progressive multifocal leukoencephalopathy -- Risk assessment -- Human viruses and MS -- References -- Chapter 7 Epilogue: conclusions and future directions -- References -- Index |
| Summary |
"Multiple sclerosis is the most common debilitating neurological disease in people under the age of forty in the developed world. Many publications cover medical and clinical approaches to the disease; however, The Biology of Multiple Sclerosis provides a clear and concise up-to-date overview of the scientific literature on the various theories of MS pathogenesis. Covering the main elements of scientific research into multiple sclerosis, the book contains chapters on the neuropathology of the disease as well as an account of the most extensively used animal model experimental autoimmune encephalomyelitis. The book contains chapters regarding the role of viruses in the development of multiple sclerosis. Viruses have long been implicated and chapters on animal models based on virus infection, as well as their possible role in the etiology of MS, are included. Of interest to MS researchers, the book is written to also be of value to postgraduate and medical students"-- Provided by publisher |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Multiple sclerosis.
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Multiple Sclerosis
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MEDICAL -- Neurology.
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HEALTH & FITNESS -- Diseases -- Alzheimer's & Dementia.
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Multiple sclerosis
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| Form |
Electronic book
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| Author |
Atkins, Gregory J
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| ISBN |
9781139839617 |
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1139839616 |
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9780511979088 |
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0511979088 |
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1283836157 |
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9781283836159 |
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1139844350 |
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9781139844352 |
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