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Title Alcoholic/non-alcoholic digestive diseases / Hitoshi Yoshiji, Kosuke Kaji, editors
Published Singapore : Springer, [2019]


Description 1 online resource
Contents Intro; Preface; Contents; Part I: Alcoholic/Non-Alcoholic Gastrointestinal Diseases; Chapter 1: Alcohol-Induced DNA Injury in Esophageal Squamous Cell Carcinoma; 1.1 Acetaldehyde, a Metabolite of Alcohol, and the Development of Esophageal Squamous Cell Carcinoma; 1.2 Blood and Saliva Acetaldehyde Concentration After Alcohol Intake; 1.3 Acetaldehyde Reacts with DNA to Form DNA Adducts and Cause Severe DNA Damage; 1.4 Conclusions; References; Chapter 2: Gastroesophageal Reflux Diseases and Lifestyle Factors; 2.1 Introduction; 2.2 Obesity; 2.3 Metabolic Syndrome; 2.4 Diabetes Mellitus
2.5 Hypertension2.6 Dyslipidemia; 2.7 Cigarette Smoking; 2.8 Alcohol Drinking; 2.9 Late Meal; 2.10 Conclusions; References; Chapter 3: Post Helicobacter pylori Gastric Diseases; 3.1 H. pylori-Negative Mucosal Injury of the Stomach; 3.1.1 H. pylori-Negative Gastric Ulcer; 3.1.2 Drug-Induced Gastric Ulcer (Recurrent Gastric Ulcer) After H. pylori Eradication; 3.2 Inflammation (Gastritis) and Acid Secretion; 3.3 Functional Dyspepsia Defined without H. pylori Infection: Hypersensitive Mucosa to Acid Exposure; 3.4 Association of Non-alcoholic Fatty Liver Disease with Gastroesophageal Diseases
3.5 ConclusionsReferences; Chapter 4: New Perspectives in Gastric Cancer: Helicobacter pylori-Uninfected Pure Signet Ring Cell Carcinoma; 4.1 Introduction; 4.2 Diagnostic Criteria for HP-Uninfected Gastric Cancer; 4.3 Characteristics of HP-Uninfected Intramucosal Pure Signet Ring Cell Carcinoma; 4.3.1 Case Presentation of HDGC; 4.3.2 HP-Uninfected Pure Signet Ring Cell Carcinoma; 4.4 Speculation about the Carcinogenic Mechanisms of HP-Uninfected Pure Signet Ring Cell Carcinoma; 4.5 Future Directions; References; Chapter 5: Role of Alcohol and Metabolic Diseases in Colorectal Carcinogenesis
5.1 Colorectal Cancer Risk Attributable to Alcohol5.2 Risk for Precancerous Lesions in the Colorectum Attributable to Alcohol; 5.3 Developmental Mechanism of Colorectal Cancer Attributable to Alcohol; 5.4 Metabolic Syndrome and Colorectal Cancer Risk; 5.5 Colorectal Cancer Risk Attributable to Metabolic Syndrome; 5.6 Risk for Precancerous Lesions in the Colorectum Attributable to Metabolic Syndrome; 5.7 Four Components of Metabolic Syndrome and Colorectal Cancer Risk; 5.8 Developmental Mechanism of Colorectal Cancer Attributable to Metabolic Syndrome; 5.9 Epilogue; References
Part II: Alcoholic/Non-Alcoholic Liver DiseasesChapter 6: Extracellular Vesicles in Alcoholic Liver Injury; 6.1 Introduction; 6.1.1 Alcoholic Liver Injury; 6.1.2 Extracellular Vesicles (EVs); 6.2 The Mechanism of EV Release and the Role of EVs in ALD/ASH; 6.2.1 Hepatocyte-Derived Extracellular Vesicles (Hep-EVs); 6.2.2 Non-parenchymal Cell-Derived Extracellular Vesicles; 6.3 EVs as Novel Biomarkers to Monitor Liver Injury in ALD/ASH; 6.3.1 Ligands and Proteins; 6.3.2 mtDNAs and miRNAs; 6.4 Conclusions; References; Chapter 7: Diabetes in Liver Disease
Summary This book describes the latest advances concerning the molecular mechanisms of and therapeutic strategies for alcohol- and non-alcohol-related digestive diseases. Alcohol abuse causes not only liver injury but can harm various organs, resulting in esophageal and colorectal cancers, GERD, pancreatitis, etc. Similar to alcoholic abuse, metabolic syndrome based on obesity and diabetes is also strongly associated with the development of various digestive diseases. Although these diseases may be differentiated by the presence or absence of alcohol intake, the pathologic findings and pathogenesis reveal a number of similarities. This volume covers clinical and basic approaches for esophageal, gastric, hepatic, colorectal and pancreatic diseases associated with alcohol abuse and metabolic syndrome; further, it discusses the roles of microbiota, oxidative stress, and apoptosis, the critical factors causing alcoholic and metabolic digestive diseases. Also, it showcases new pathological and therapeutic perspectives in gastric and pancreatic cancers. Alcoholic/Non-Alcoholic Digestive Diseases will provide invaluable information for doctors specializing in gastroenterology and hepatology and researchers seeking new research on digestive diseases based on alcohol consumption and obesity
Notes Includes index
7.1 Prevalence of Impaired Glucose Tolerance (IGT) and Diabetes Mellitus in Patients with Chronic Liver Disease (CLD)
Online resource; title from digital title page (viewed on July 18, 2019)
Subject Digestive organs -- Diseases.
Digestive System Diseases
Alcohol-Induced Disorders
Risk Factors
Digestive organs -- Diseases
Genre/Form Electronic books
Form Electronic book
Author Yoshiji, Hitoshi, editor
Kaji, Kosuke, editor
ISBN 9789811314650