Title RNA polymerases as molecular motors / edited by Henri Buc, Terence Strick

Published Cambridge, UK : RSC Pub., ©2009

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Description 1 online resource (xix, 331 pages) : illustrations (chiefly color) Series RSC biomolecular sciences RSC biomolecular sciences. Contents Where it begins : an overview of promoter recognition and open complex formation / Stephen Busby, Annie Kolb and Henri Buc -- Opening the DNA at the promoter : the energetic challenge / Bianca Sclavi -- Intrinsic in vivo modulators : negative supercoiling and the constituents of the bacterial nucleoid / Georgi Muskhelishvili and Andrew Travers -- Transcription by RNA polymerases : from initiation to elongation, translocation and strand separation / Thomas A. Steitz -- Single-molecule FRET analysis of the path from transcription initiation to elongation / Achillefs N. Kapanidis and Shimon Weiss -- Real-time detection of DNA unwinding by Escherichia coli RNAP : from transcription initiation to termination / Terence R. Strick and Andrey Revyakin -- The engine and the brake / Henri Buc and Terence Strick -- Substrate loading, nucleotide addition, and translocation by RNA polymerase / Jinwei Zhang and Robert Landick -- Regulation of RNA polymerase through its active center / Sergei Nechaev, Nikolay Zenkin and Konstantin Severinov -- Kinetic modeling of transcription elongation / Lu Bai, Alla Shundrovsky and Michelle D. Wang -- Mechanics of transcription termination / Evgeny Nudler -- Past, present, and future of single-molecule studies of transcription / Carlos Bustamante and Jeffrey R. Moffitt Summary The cell can be viewed as a 'collection of protein machines' and understanding these molecular machines requires sophisticated cooperation between cell biologists, geneticists, enzymologists, crystallographers, chemists and physicists. To observe these machines in action, researchers have developed entirely new methodologies for the detection and the nanomanipulation of single molecules. This book, written by expert scientists in the field, analyses how these diverse fields of research interact on a specific example - RNA polymerase. The book concentrates on RNA polymerases because they play a Bibliography Includes bibliographical references and index Subject RNA polymerases. Molecules. Genetic transcription. Mathematical models. Gene expression. Adenosine triphosphatase. Hydrolases. Phosphotransferases. Transferases. Enzymes. Models, Molecular Transcription, Genetic Molecular Motor Proteins DNA-Directed RNA Polymerases Biochemical Phenomena Models, Theoretical Gene Expression RNA Nucleotidyltransferases Multiprotein Complexes Adenosine Triphosphatases Genetic Phenomena Chemical Phenomena Macromolecular Substances Nucleotidyltransferases Investigative Techniques Acid Anhydride Hydrolases Chemicals and Drugs Hydrolases Phosphotransferases Analytical, Diagnostic and Therapeutic Techniques and Equipment Phenomena and Processes Transferases Enzymes Enzymes and Coenzymes mathematical models. enzyme. SCIENCE -- Life Sciences -- Molecular Biology. Transferases Phosphotransferases Mathematical models Hydrolases Genetic transcription Gene expression Enzymes Adenosine triphosphatase Molecules RNA polymerases Genre/Form Electronic books Form Electronic book Author Buc, Henri Strick, Terence ISBN 9781847559982 1847559980 9780854041343 0854041346

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