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Title The new paradigm of immunity to tuberculosis / Maziar Divangahi, editor
Published New York, NY : Springer, ©2013


Description 1 online resource
Series Advances in experimental medicine and biology, 0065-2598 ; v. 783
Advances in experimental medicine and biology ; v. 783.
Contents Epidemiology of Tuberculosis Immunology / G.J. Fox, D. Menzies -- Host-Pathogen Specificity in Tuberculosis / Tania Di Pietrantonio, Erwin Schurr -- Genetic Determinants of Susceptibility to Mycobacterial Infections: IRF8, A New Kid on the Block / S. Salem, P. Gros -- Evolution of Mycobacterium tuberculosis / Marcel A. Behr -- Mycobacterium tuberculosis Genes Involved in Regulation of Host Cell Death / Volker Briken -- Dying to Live: How the Death Modality of the Infected Macrophage Affects Immunity to Tuberculosis / Maziar Divangahi, Samuel M. Behar -- Cytokines in the Balance of Protection and Pathology During Mycobacterial Infections / Egídio Torrado, Andrea M. Cooper -- Antigen-Specific CD8+ T Cells and Protective Immunity to Tuberculosis / Samuel M. Behar -- Foxp3+ Regulatory T Cells in Tuberculosis / Ryan P. Larson, Shahin Shafiani -- CD1a, CD1b, and CD1c in Immunity Against Mycobacteria / Ildiko Van Rhijn, Dalam Ly, D. Branch Moody -- CD1d and Natural Killer T Cells in Immunity to Mycobacterium tuberculosis / Pooja Arora, Erin L. Foster -- The Role of B Cells and Humoral Immunity in Mycobacterium tuberculosis Infection / Lee Kozakiewicz, Jiayao Phuah, JoAnne Flynn -- Looking Within the Zebrafish to Understand the Tuberculous Granuloma / Lalita Ramakrishnan -- Immunization Strategies Against Pulmonary Tuberculosis: Considerations of T Cell Geography / Carly N. Horvath, Zhou Xing
Summary This book illustrates the intimate relationship between alveolar macrophages and Mycobacterium tuberculosis (M.tb.), and the former's role in both innate and adaptive immunity against M.tb. It covers research done over the last decade. It also explores the role of macrophage death following infection with M.tb. in determining whether successful immunity is stimulated, or whether clinical disease develops; furthermore, the function of host lipid mediators in macrophage death modality are addressed. The book also illustrates how the balance between prostaglandins and lipoxins determines whether infected macrophages undergo apoptosis or necrosis, which is the ultimate factor in the outcome of infection. Finally, it is a synthesis of the authors' recent studies and the studies of others to offer a new understanding of immunity to tuberculosis
Analysis Medicine
Monoclonal antibodies
Medical Microbiology
Notes Includes index
Bibliography Includes bibliographical references and index
Subject Tuberculosis -- Immunological aspects
Tuberculosis -- Vaccination.
Mycobacterial diseases.
Gram-positive bacterial infections.
Bacterial diseases.
Biological products -- Therapeutic use.
Immunity, Innate -- immunology
Macrophages, Alveolar -- immunology
Mycobacterium Infections
Immunotherapy, Active
Actinomycetales Infections
Gram-Positive Bacterial Infections
Bacterial Infections
Biological Therapy
Bacterial Infections and Mycoses
Analytical, Diagnostic and Therapeutic Techniques and Equipment
Tuberculosis -- immunology
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Tuberculosis -- Immunological aspects.
Tuberculosis -- Vaccination.
Form Electronic book
Author Divangahi, Maziar
ISBN 9781461461111